XRCC1 and DNA strand break repair.

By K. Caldecott. DNA Repair, 2003

625 citations recorded by the source corpus.

DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base excision repair, or directly from damage to deoxyribose. Because single-strand breaks are induced by endogenous reactive molecules such as reactive oxygen species, these lesions pose a continuous threat to genetic integrity. XRCC1 protein plays a major role in facilitating the repair of single-strand breaks in mammalian cells, via an ability to interact with multiple enzymatic components of repair reactions. Here, the protein-protein interactions facilitated by XRCC1, and the repair processes in which these interactions operate, are reviewed. Models for the repair of single-strand breaks during base excision repair and at direct breaks are presented.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ea0bfab4fe828c0d5fdc22194fa313b07bcfaf19

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In Molecular Biology

Citations in the corpus

The PARP superfamily (2004, background): “(46) The role of PARP-1 during the repair of single-strand breaks in mammalian cells is now better understood, not only in vitro where PARP-1 activity facilitates the whole process, but also in living cells where PAR synthesis at sites of DNA lesions plays an essential role in the recruitment kineti”
Poly(ADP-ribose): novel functions for an old molecule (2006, background): “Prevention of XRCC1 recruitment affects the subsequent repair process, as XRCC1 conducts the SSBR/BER machinery by stimulating most of the repair enzyme”
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings (2011, background): “It is well established that an important role of PARP in SSBR is the recruitment of XRCC1 (Caldecott, 2003; El-Khamisy et al., 2003).”
Single-strand break repair and genetic disease (2008, positive): “Arguably the most important of these is X-ray repair cross-complementing protein 1 ( XRCC1 ), which functions as a molecular scaffold that interacts with, stabilizes, and stimulates multiple enzymatic components of the SSBR proces”
Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair (2010, background): “As a result of multiple interactions with a number of repair proteins XRCC1 plays a crucial role in the coordination of BER and SSB repair [189].”
Repair and genetic consequences of endogenous DNA base damage in mammalian cells. (2004, background): “Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair.”