Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair

By R. P. Rastogi, Richa, Ashok Kumar, M. Tyagi, Rajeshwar Prasad Sinha. Journal of Nucleic Acids, 2010

1,222 citations recorded by the source corpus.

DNA is one of the prime molecules, and its stability is of utmost importance for proper functioning and existence of all living systems. Genotoxic chemicals and radiations exert adverse effects on genome stability. Ultraviolet radiation (UVR) (mainly UV-B: 280–315 nm) is one of the powerful agents that can alter the normal state of life by inducing a variety of mutagenic and cytotoxic DNA lesions such as cyclobutane-pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and their Dewar valence isomers as well as DNA strand breaks by interfering the genome integrity. To counteract these lesions, organisms have developed a number of highly conserved repair mechanisms such as photoreactivation, base excision repair (BER), nucleotide excision repair (NER), and mismatch repair (MMR). Additionally, double-strand break repair (by homologous recombination and nonhomologous end joining), SOS response, cell-cycle checkpoints, and programmed cell death (apoptosis) are also operative in various organisms with the expense of specific gene products. This review deals with UV-induced alterations in DNA and its maintenance by various repair mechanisms.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/d11b9812b969c7d3d30c2829e21f6da372ae74ec

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

In Plant Science

R. Aminov

Citations in the corpus

Biological Aspects in Food Preservation by Ultraviolet Light: a Review (2013, background): “2(b)) (Rastogi et al. 2010).”
Factors enhancing fish sperm quality and emerging tools for sperm analysis (2014, background): “Antibodies have been developed against cyclobutanepyrimidine dimers (CPDs) or 6–4 photoproducts (6-4PPs), typically induced byUV irradiation (Rastogi et al., 2010) used in aquaculture to inactivate the sperm genome in gynogenetic processes.”
Mechanisms of DNA damage, repair and mutagenesis (2017, background): “Sunlight is composed of 5.1% UV-A, 0.3% UV-B, 62.7% visible light, and 31.9% infrared, as the hazardous UV-C is most- ly filtered out by the ozone layer [Davies, 1995].”
Horizontal Gene Exchange in Environmental Microbiota (2011, background): “One of the major targets is DNA where UVB irradiation results in the formation of cyclobutane-pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and DNA strand breaks, thus leading to the induction of a number of repair mechanisms, including the SOS response (Rastogi et al., 2010).”