Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

By S. Zeissig, N. Bürgel, D. Günzel, J. Richter, J. Mankertz, U. Wahnschaffe, A. J. Kroesen, M. Zeitz, M. Fromm, J. Schulzke. Gut, 2006

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Subfields: Genetics, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/e9c9ad32a70d846d9768e9145ab08a86a61c3f28

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Citations in the corpus

Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases (2015, background): “Clinical studies show decreased expression and redistribution of barrierforming proteins, including occludin, claudin-3, -5, -8, and JAM-A, and increased expression of pore-forming claudin-2 in CD patients.(60,61) In UC patients, decreased expression and redistribution of occludin, claudin-1, -4, an”
Regulation of intestinal epithelial permeability by tight junctions (2012, background): “Clinical studies show decreased expression and redistribution of barrier-forming proteins (occludin, claudin-3, claudin-5, claudin-8, and JAM-A), and increased expression of poreforming claudin-2 in CD patients [250, 251].”
Intestinal permeability – a new target for disease prevention and therapy (2014, background): “The group of Schulzke an co-workers showed a disturbance of the barrier function which was accompanied by a downregulation of claudin-1, 3, 5, 7 and 8, and an upregulation of claudin-2, a pore-forming claudin, together with a re-distribution of claudin-5 and −8 off the tight junction domain of the e”
Tight junctions and the modulation of barrier function in disease (2008, background): “…pattern of characteristic claudins is altered in Crohn’s disease (Weber and Turner 2007) with a concomitant eVect on the integrity of TJ strands: Zeissig et al. (2007) showed by freeze–fracture electron microscopy that the overall number of TJ strands sealing the epithelial layer is reduced…”
Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut (2015, background): “Furthermore, an ex vivo study using Ussing chambers on colonic biopsies from CD patients [31] demonstrated a spatially uniform increase in transepithelial conductivity despite the presence of minimal mucosal erosions.”
Human Intestinal Barrier Function in Health and Disease (2016, background): “Increased expression of claudin-2 is also observed in the intestinal epithelium of inflammatory bowel disease (IBD) patients with active disease and is associated with barrier dysfunction and ‘leak-flux’ diarrhea.(19) TNF-α has been shown to upregulate the expression of claudin-2 via phosphatidylino”
Tight Junction Pore and Leak Pathways: A Dynamic Duo (2011, background): “For example, claudin-4 can be classified as either sealing or as anionselective, pore forming (56).”
Intestinal barrier function: molecular regulation and disease pathogenesis. (2009, background): “Initial studies reported a downregulation in occludin expression in patients with IBD, with no change in claudin-1 expression(235); however, the role occludin may play in barrier dysfunction has been questioned since occludin-deficient mice have normal intestinal barrier function.(236) There are a n”