Autophagy in Health and Disease: A Double-Edged Sword

By T. Shintani, D. Klionsky. Science, 2004

2,649 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/e967c660067ba19a65ddb844105b22e3738f204b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. N. Mizushima
2. D. Klionsky
3. Beth Levine
4. I. Slaninová
5. Guido Kroemer
6. V. Deretic
7. M. Komatsu
8. Zhifen Yang

In Molecular Biology

1. D. Klionsky
2. N. Mizushima
3. Beth Levine
4. Guido Kroemer
5. M. Sandri
6. I. Slaninová
7. Eric H. Baehrecke
8. Y. Ohsumi

In Neurology

1. N. Mizushima
2. Beth Levine
3. D. Klionsky
4. W. Ding
5. Guido Kroemer
6. Xiao-Ming Yin
7. M. Komatsu
8. Eric H. Baehrecke

Citations in the corpus

• Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons (2006, background): “The rate of fission and autophagy might be critical in determining neuronal survival or death (Shintani and Klionsky, 2004; Levine and Yuan, 2005).”
• Unveiling the roles of autophagy in innate and adaptive immunity (2007, background): “The broad spectrum of autophagy functions is intricately linked to a wide range of health and disease state”
• Lysosomes and autophagy in cell death control (2005, background): “Depending on the context and intensity, macro-autophagy (which we will hereafter refer to as 'autophagy') can protect cells against cell death or mediate so-called autophagic cell deat”
• Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. (2007, background): “In addition to survival of starvation, autophagy has been implicated in many aspects of health and development, including aging, programmed cell death, pathogenic infection, stress responses, neurodegenerative and muscle disorders, cellular remodeling, cancer, and cell growth [1, 6].”
• Autophagy: process and function. (2007, background): “Autophagy is a general term for the degradation of cytoplasmic components within lysosomes (Cuervo 2004; Levine and Klionsky 2004; Shintani and Klionsky 2004; Klionsky 2005, 2007; Mizushima and Klionsky 2007).”
• Methods for Monitoring Autophagy from Yeast to Human (2007, neutral): “Non‐specific autophagy can be separated into seven steps: (1) Induction; (3) Vesicle nucle‐ ation; (4) Vesicle expansion and completion; (5) Retrieval; (6) Fusion; (7) Breakdown; (8) Efflux.”
• Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice (2005, background): “In humans, autophagy has been implicated in several pathological conditions ( Shintani and Klionsky, 2004 ); e.g., low levels of autophagy were described in some malignant tumors (Liang et al., 1999).”
• Hypoxia-induced autophagy: cell death or cell survival? (2010, neutral): “com [1].”