Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.

By Yang Shi, F. Lan, Caitlin Matson, P. Mulligan, J. Whetstine, P. Cole, R. Casero, Yang Shi. Cell, 2004

3,423 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e91170f4090115a90d7de1f3287c70743fb10788

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Citations in the corpus

The Role of Snail in EMT and Tumorigenesis (2013, background): “LSD1 is the first identified histone demethylase that specifically removes methylations of H3K4, a transcriptional mark associated with gene activation [73].”
Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications (2020, background): “demethylase 1 (LSD1) is a flavin adenine dinucleotide (FAD)-dependent amine oxidase that remodels chromatin by the demethylation of histone H3 Lys4 (H3–K4) [103,104], in which a detectable amount of ROS are found as the byproduct of its chromatin modification during the”
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (2006, background): “Shi and colleagues demonstrated that LSD1/ BHC110 can speciﬁcally demethylate mono-and dimethyl H3K4 in a FAD (ﬂavin adenine dinucleotide)-dependent oxidative reaction (Shi et al., 2004).”
Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma (2018, unknown): “Identification of LSD1 (lysine-specific demethylase 1)/KDM1A in 2004, which is a histone demethylase, revealed that protein methylation is dynamically regulated [9].”
PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “In these cells, LSD1 represses the transcription of PGC-1α by removing the methyl group from mono-methylated and di-methylated lysine 4 of histone H3 (H3K4) [26, 27].”
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact (2012, unknown): “Subsequent to the discovery of KDM1A, an additional class of KDMs was discovered.”
The Histone Demethylase JMJD2B Plays an Essential Role in Human Carcinogenesis through Positive Regulation of Cyclin-Dependent Kinase 6 (2011, background): “Although histone methylation had been thought to be irreversible, lysine specific demethylase 1, LSD1, was discovered to be the first example of a demethylase that can reverse histone H3 lysine 4 methylation status (4, 5).”
The JmjC domain‐containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene (2012, background): “Lysine-specific demethylase 1 (KDM1; also known as LSD1) was the first histone demethylase discovered and it belongs to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases.(4) Subsequently, the first JmjC-containing histone demethylase (KDM2A; also known as JHDM1a/FBXL1”
Epigenetics Analysis and Integrated Analysis of Multiomics Data, Including Epigenetic Data, Using Artificial Intelligence in the Era of Precision Medicine (2019, background): “As for biochemical analysis of epigenetic regulators, such as histone acetyltransferases, histone methyltransferases and histone demethylases, various procedures were developed in the late 20th and early 21st centuries [43,49,51,76].”