Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

By Lin-Feng Chen, W. Fischle, E. Verdin, W. Greene. Science, 2001

1,181 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e902313ffb2114a16c172905484e8fd583dc44fe

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Citations in the corpus

IκBα and p65 Regulate the Cytoplasmic Shuttling of Nuclear Corepressors: Cross-talk between Notch and NFκB Pathways (2003, methodology): “…acid and thyroid hormone; TAD, transactivation domain; TNF- , tumor necrosis factor alpha; TSA, trichostatin A. © 2003 by The American Society for Cell Biology 491 phorylation (Zhong et al., 1998; Carter et al., 1999; Madrid et al., 2001; Sizemore et al., 2002) and acetylation (Chen et al., 2001).”
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. (2003, background): “Besides HDAC-2, association of NF- B with HDAC-1 and HDAC-3 has also been observed recently (77, 467, 468).”
Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. (2011, background): “[37] have found that SCFAs attenuate the production of TNF-α by human blood mononuclear cells.”
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “The interaction of STAT3 with p300 or other HATs is also required for STAT3-dependent transcription [63] and reversible acetylation of RelA regulates the duration of nuclear NF-kB activity [23].”
NF-κB RelA Phosphorylation Regulates RelA Acetylation (2005, methodology): “Supernatants were immunoprecipitated as previously described ( 4 ), with 100 l of a 50% slurry of anti-HA agarose (Covance).”
To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis (2003, background): “Acetylation of NF-kB subunits adds another level of regulation, as acetylation of RelA prevented its association with newly synthesized IkBa and interaction with corepressor HDACs (Ashburner et al., 2001; Chen et al., 2001).”