Complete sequencing and characterization of 21,243 full-length human cDNAs

By T. Ota, Yutaka Suzuki, T. Nishikawa, Tetsuji Otsuki, T. Sugiyama, R. Irie, Ai Wakamatsu, K. Hayashi, Hiroyuki Sato, Keiichi Nagai and 147 more. Nature Genetics, 2004

946 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e864de97bb2f1d1582004ff9502cd6edc511caa3

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TRIM family proteins: retroviral restriction and antiviral defence (2005, background): “Subsequently, the TRIM family grew slowly, until the availability of new genome sequences combined with a functional genomics approach enabled many new members to be identifie”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “Although lncRNAs are found across many taxa, and many crucial discoveries have been made in plants, fungi, and invertebrates (Gelbart and Kuroda 2009; Au et al. 2011), we largely limit our discussion to mammalian examples, with occasional reference to lncRNAs of other taxa.”
TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death (2005, methodology): “This work was supported in part by Grant-in-Aids for Scientific Research (B) from Japan Society for the Promotion of Science and Grant-in-Aids for Scientific Research on Priority Areas (C) from the Ministry of Education, Science, Sports and Culture.”
Genome-wide characterization of transcriptional start sites in humans by integrative transcriptome analysis. (2011, background): “We first selected 16,080 nonredundant cDNAs from the MGC and FLJ collections whose 59-ends overlapped the TSCs (Supplemental Figs.”
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004, neutral): “41,118 H-Inv cDNAs were sequenced by the Human Full-Length cDNA Sequencing Project (Ota et al. 1997; Yudate et al. 2001; Ota et al. 2004) at the Helix Research Institute, the Institute of Medical Science at the University of Tokyo, and the Kazusa DNA Research Institute (20,999 sequences in total);…”
The rise of regulatory RNA (2014, background): “There is also increasing evidence of intersecting pathways, such as RNA editing and modification, in these networks 93–96 .”
Large-scale prediction of long non-coding RNA functions in a coding–non-coding gene co-expression network (2011, background): “Large-scale analyses of full-length cDNA sequences have detected large numbers of long-non-coding RNAs (lncRNAs) in human (1), mouse (2) and fly (3).”
Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing (2006, background): “We have developed a new approach that will provide complementary information for global transcriptome analysis, such as recent studies with human and mouse full-length cDNA libraries (44,45).”
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (2004, background): “Other large-scale cDNA cloning efforts include two programs in Japan and one in Germany (Wiemann et al. 2001; Okazaki et al 2002; Ota et al 2004).”
AceView: a comprehensive cDNA-supported gene and transcripts annotation (2006, methodology): “Indeed, we compared the high quality full-length cDNA libraries made by Sugano using the oligo-capping method in either the nematode Caenorhabditis elegans or human (all sequences are in GenBank [7,9]).”
A User's Guide to the Encyclopedia of DNA Elements (ENCODE) (2011, methodology): “DNaseI hypersensitive sites (DHSs) are being mapped by two techniques: (i) capture of free DNA ends at in vivo DNaseI cleavage sites with biotinylated adapters, followed by digestion with a TypeIIS restriction enzyme to generate , 20 bp DNaseI In black are two mRNA transcripts (U58658/AK097045) from”