A chemical switch for inhibitor-sensitive alleles of any protein kinase
By Anthony C. Bishop, Jeffrey A. Ubersax, Dejah T. Petsch, D. Matheos, Nathanael S. Gray, Justin D. Blethrow, Eiji Shimizu, J. Tsien, Peter G. Schultz, M. Rose and 3 more. Nature, 2000
1,081 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e835b06ed61e0eb5eae3c083dbd150e8655c85ce
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In Cell Biology
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Citations in the corpus
- Features of selective kinase inhibitors. (2005, background): “References: CDC28 [98], Ire1 [104], Apg1 [110], Cla4 [111], Elm1 [112], p110γ [103, 113].”
- Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs (2009, background): “, 1NM-PP1), treatment with this drug allows the selective inhibition of CDK1 (26).”
- DREADDs for Neuroscientists (2016, methodology): “…IIα (F89G, CAMK IIα-as1) and CDK2 (F80G, CDK2-as1) K252a and PPI analogues Bishop et al., 1998 Rapamycin-insensitive TOR complex 2 TORC2 V2227L BEZ235 Bishop et al., 2000 ATP-binding pocket mutations in EphB1, EphB2 and EphB3 Ephb1T697G, Ephb2T699A, and Ephb3T706A PP1 analogues Soskis et al.,…”
- Differential network biology (2012, background): “…genetic interaction mapping of analog-sensitive kinase mutants in the presence of the relevant compound, which specifically inhibits the kinase (Bishop et al , 2000) to more accurately ascertain which effects on signaling cascades are primary and which occur downstream (J Kliegman and K…”
- Regulated Ire1-dependent decay of messenger RNAs in mammalian cells (2009, background): “Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.”
- A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. (2004, background): “A tpk1wimp strain, which has weak constitutive PKA activity (Cameron et al. 1988), had reduced nuclear Sfp1CFP (Fig.”