NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.

By Laetitia Agostini, Fabio Martinon, K. Burns, M. McDermott, P. Hawkins, J. Tschopp. Immunity, 2004

1,817 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/e6470894378414537626e2dd6485b0a32b08f502

How researchers see this paper

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In Immunology

1. J. Tschopp
2. T. Kanneganti
3. Guido Kroemer
4. M. Lamkanfi
5. Kate Schroder
6. L. Zitvogel
7. G. Núñez
8. T. Mogensen

In Molecular Biology

1. J. Tschopp
2. T. Kanneganti
3. Kate Schroder
4. M. Lamkanfi
5. G. Núñez
6. V. Dixit
7. S. Man
8. C. A. Dinarello

In Sensory Systems

1. J. Tschopp

Citations in the corpus

• The NLRP3 Inflammasome Mediates in vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA (2009, background): “It has been demonstrated that the NLR protein, NLRP3, together with its adapter protein, Apoptotic Speck protein containing a CARD (ASC), regulate IL-1β maturation through the formation of a biochemical complex called the inflammasome (Agostini et al., 2004).”
• The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases (2011, background): “In vitro ectopic expression systems have demonstrated that NLRP3 can activate caspase-1 in the presence of ASC (9).”
• The Inflammasome: A Caspase-1 Activation Platform Regulating Immune Responses and Disease Pathogenesis (2009, background): “The disease-associated NLRP3 mutations result in enhanced activation of caspase-1 and secretion of IL-1β by causing constitutive activation of the NLRP3 inflammasom”
• The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis (2010, positive): “These hereditary periodic-fever syndromes are Muckle-Wells syndrome (MWS), familial cold autoinflammatory syndrome (FACS), and neonatal-onset multisystem inflammatory disease (NOMID), and they are collectively referred to as the Cryopyrin-associated periodic syndromes (CAPS) (Agostini et al., 2004).”
• Inflammasomes and their roles in health and disease. (2012, background): “Consequently, ASC is essential for assembly and activation of these PYD-containing inflammasomes (Agostini et al. 2004, Elinav et al. 2011, Kanneganti et al. 2006, Mariathasan et al. 2006, Sutterwala et al. 2006).”