Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

By G. Barreto, A. Schäfer, J. Marhold, D. Stach, S. Swaminathan, V. Handa, Gabi Döderlein, Nicole Maltry, Wei Wu, F. Lyko and 1 more. Nature, 2007

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DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 (2008, positive): “Currently, the enzymes that may cooperate with Gadd45 to perform demethylation have remained unknown, though a link to DNA repair has been suggested (Barreto et al., 2007), and here candidate cooperating enzymes are evaluated.”
Epigenetic inheritance during the cell cycle (2009, background): “, the mechanisms and enzymatic activities that are responsible for DNA demethylation in mammals — although potentially linked to DNA repair — are controversia”
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “BER is used to correct damaged bases or mismatched base pairs (e.g., G:T mismatch), whereas NER can repair bulky DNA lesions formed by exposure to radiation or chemicals.”
Linking DNA methylation and histone modification: patterns and paradigms (2009, background): “Several studies now suggest that active DNA demethylation might be accomplished through a process of DNA repai”
Epigenetic reprogramming and induced pluripotency (2009, background): “However, the nature and existence of demethylating enzymes in mammals remains highly controversial (Barreto et al., 2007; Bhattacharya et al., 1999; Hendrich et al., 2001; Jin et al., 2008; Kangaspeska et al., 2008; Metivier et al., 2008).”