Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties
By L. Marín, E. Miguélez, C. J. Villar, F. Lombó. BioMed Research International, 2015
717 citations recorded by the source corpus.
Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become bioactive at human body, these polyphenols must undergo diverse intestinal transformations, due to the action of digestive enzymes, but also by the action of microbiota metabolism. After elimination of sugar tailoring (generating the corresponding aglycons) and diverse hydroxyl moieties, as well as further backbone reorganizations, the final absorbed compounds enter the portal vein circulation towards liver (where other enzymatic transformations take place) and from there to other organs, including behind the digestive tract or via blood towards urine excretion. During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities. This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.
Subfields: Biochemistry, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/c7bb4a23267553aa050c46c598e37ac00c062acd
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Citations in the corpus
- Bioactivity of dietary polyphenols: The role of metabolites (2020, background): “Bacteroides ovatus, Adlercreutzia equlifaciens, Ruminococcus productus, Streptococcus intermedius, Lactobacillus mucosae, Enterococcus faecium and Finegoldia magna are involved in the production of equol from daidzein (Maruo et al. 2008).”
- Phenolic Compounds in Honey and Their Associated Health Benefits: A Review (2018, background): “The microflora of the colon also transforms the aglycones into various metabolites that can either be excreted from the feces, or be absorbed by the liver within the enteropathic recirculation of the bile excretion and be further conjugated by specific enzymes as previously explained [42].”
- Gut microbiota functions: metabolism of nutrients and other food components (2017, background): “Lachnospiraceae CG19‐1, and Eubacterium ramulus [88, 89].”
- The Role of Polyphenols in Human Health and Food Systems: A Mini-Review (2018, background): “Though the mechanisms are not entirely understood, it is hypothesized that polyphenol metabolites may promote beneficial gut bacteria, while inhibiting invasive species (68, 69).”