Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.

By S. Ivanov, S. Liao, A. Ivanova, A. Danilkovitch-Miagkova, N. Tarasova, G. Weirich, M. Merrill, M. Proescholdt, E. Oldfield, Joshua D. Lee and 5 more. American Journal of Pathology, 2001

672 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e5ef343328e2ba36e18b37ecab562be4601b82de

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Citations in the corpus

Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. (2003, background): “It has been postulated that cell surface carbonic anhydrases regulate acid-base balance to optimize conditions in the tumor invasiveness (10).”
Hypoxia and cancer (2007, background): “3), has been reported to regulate the pHe [36], and we propose that it may contribute to an increase in the pHi through C1 HCO 3 exchanger uptake of HCO 3 .”
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “The ca12 gene is also induced in hypoxia [23, 145], via a HIF-1dependent mechanism [24].”
Acidity generated by the tumor microenvironment drives local invasion (2013, background): “These adaptations can involve, inter alia, upregulation of the sodium-hydrogen exchange (NHE-1) or carbonic anhydrase (CA-IX) (21-23) .”
Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. (2001, background): “Carbonic anhydrase XII has very recently been localized to the ductal epithelium where it may promote tumor invasion by modifying the extracellular pH (32).”