Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy.

By M. Bui, D. Seligson, Ken‐ryu Han, A. Pantuck, F. Dorey, Yunda Huang, Steve Horvath, B. Leibovich, S. Chopra, S. Liao and 5 more. Clinical Cancer Research, 2003

688 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/04267110f42d824223233b60bcb4d752e0dc708f

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. G. Semenza
2. A. Mayer
3. J. Chiche
4. Adrian L. Harris
5. M. Brahimi-Horn
6. J. Pouysségur
7. P. Vaupel
8. P. Ratcliffe

Citations in the corpus

• Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma (2005, background): “Interestingly, though upregulation of CAIX is commonly observed in RCC (25), reduced staining has been correlated with poorer prognosis in RCC in a recent clinical series (4).”
• Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “Only one case reported that low expression of CAIX in RCC tumours is a factor of bad prognosis [183].”
• Hypoxia in cancer: significance and impact on clinical outcome (2007, result): “Surprisingly, a study of 321 patients with renal cell cancer showed exactly the opposite, with poorer survival being found in patients with lower CA IX expression [77].”