Silencing by small RNAs is linked to endosomal trafficking

By Young Sik Lee, S. Pressman, Arlise P. Andress, Kevin Kim, Jamie L. White, Justin J. Cassidy, Xin Li, Kim Lubell, Do-Hwan Lim, I. Cho and 5 more. Nature Cell Biology, 2009

242 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e5c6c4b4a19e4e9c137502240875b7316221779a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. L. Rajendran
2. F. Sánchez‐Madrid
3. C. Théry
4. M. Mittelbrunn
5. K. Simons
6. C. Dart
7. G. Nicolson

In Molecular Biology

1. L. Rajendran
2. Edit I. Buzás
3. W. Filipowicz
4. H. Siomi
5. Raymond Schiffelers
6. Imre Mäger
7. Inga Loedige
8. Jacek Krol

Citations in the corpus

• Functional delivery of viral miRNAs via exosomes (2010, background): “Because RISC proteins have been detected in exosomes (25, 33), it is tempting to speculate that miRNA loading into exosomes is controlled by RISC-MVE association.”
• Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “It is important to bear in mind that miRNAs are part of a large multimolecular complex, miRISC, and their precursors associate with multiple RNA-binding proteins.”
• Subcellular targeting strategies for drug design and delivery (2010, background): “Both miRNAs and siRNAs are now known to require membrane trafficking through functional MVB”
• Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, background): “Second, blockage of the turn-over of MVBs into lysosomes could lead to the over-accumu-lation of miRISCs, whereas blockage of the formation of MVBs resulted in the loss of miRISCs [66].”
• Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells (2011, background): “Blocking MVB formation by ESCRT depletion results in impaired miRNA silencin”
• The widespread regulation of microRNA biogenesis, function and decay (2010, background): “melanogaster and mammalian cells have identified MVBs, specialized late-endosomal compartments, as organelles contributing to miRNA functio”
• Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper (2017, background): “[11] Thus, EVs in the small size range likely represent vesicles heterogeneous in origin, with an unknown portion coming from MVBs.”