Functional delivery of viral miRNAs via exosomes

By D. Pegtel, Katherine Cosmopoulos, D. Thorley-Lawson, M. V. van Eijndhoven, Erik S. Hopmans, Jelle L Lindenberg, T. D. de Gruijl, T. Würdinger, Jaap M Middeldorp. Proceedings of the National Academy of Sciences of the United States of America, 2010

1,635 citations recorded by the source corpus.

Subfields: Cancer Research, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dc6dff409acd1865b095e6873c475f2ce53ae01f

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Citations in the corpus

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions (2012, background): “However, the size distribution of shuttle RNA, as shown here and by others (53,54), extends well beyond the 20–23 nt size of miRNAs and is mostly in the range of 20 to 200 nt.”
SORTING IT OUT: REGULATION OF EXOSOME LOADING (2014, background): “The RNA content of exosomes is enriched in small RNA species including miRNAs, which have been demonstrated to be functional in the recipient cells [3, 4, 30, 58, 59].”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “Again, transferred miRNAs are functional because they down-regulate target gene expression in recipient cells (Pegtel et al., 2010).”
MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles (2013, neutral): “Exosomes are membrane vesicles that contain RNA molecules including messenger RNAs (mRNAs) and miRNAs, which can be transferred between cells and thus affect the protein production of recipient cells [25-27].”
Routes and mechanisms of extracellular vesicle uptake (2014, background): “EVs are also being explored as natural vectors for therapeutic delivery, with some early studies showing great potential (20,137,138).”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “For example, Epstein-Barr virus (EBV) represses the expression of EBV target genes in non-infected cells by the transfer of viral miRNAs to subcellular sites of gene repression in recipient cells via exosomes [130]; the vehicles are also involved in the N-terminal modification of prion proteins (PrP”
Influence of storage condition on exosome recovery (2016, neutral): “They contain various molecular constituents of their cell origin, such as proteins [9], mRNAs [10], and microRNAs [10,11].”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “There must be a way through this maze, as so far, the functional transfer of nucleic acids has been described both in culture as well as in vivo (e.g., Pegtel et al. 2010; Ridder et al. 2014; Lai et al. 2015).”
Characterization of extracellular circulating microRNA (2011, background): “Recently, it has been suggested that extracellular miRNA entrapped in exosomes to be involved in intercellular communication (12,14,15).”
Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. (2014, neutral): “Circulating miRNAs are actively transported, either by the inclusion in microvesicles/exosomes (9, 11, 12) or by binding to RNA-binding proteins (21, 22), allowing protection from ribonuclease-dependent degradation.”