The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.
By Tony Gutschner, M. Eissmann, J. Hsu, Youngsoo Kim, G. Hung, A. Revenko, G. Arun, Marion Stentrup, Matthias Gross, A. Macleod and 2 more. Cancer Research, 2013
1,024 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4e653ebbeea1d6227cbcf15658ddcd8b0ef54c4b
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In Cancer Research
- John S. Mattick
- Marcel E. Dinger
- Stefanie Dimmeler
- Subhrangsu S. Mandal
- Milad Soleimani
- Shizuka Uchida
- A. Bhan
- Jichun Yang
In Molecular Biology
- Marcel E. Dinger
- John S. Mattick
- Thomas Braun
- Stefanie Dimmeler
- Subhrangsu S. Mandal
- Milad Soleimani
- Shizuka Uchida
- A. Bhan
Citations in the corpus
- Long Non-Coding RNA in the Pathogenesis of Cancers (2019, background): “It has been shown that the expression of MALAT1 in NSCLC tissues is higher than that in adjacent tissues, and NSCLC patients with high MALAT1 expression have poor overall survival (OS) [50,52,53].”
- Long noncoding RNAs and the genetics of cancer (2013, background): “A recent study indicated that MALAT1 may also have a role in the regulation of gene expression, but not alternative splicing, in lung metastasis, highlighting the controversial nature of MALAT1’s molecular mechanism (Gutschner et al, 2013).”
- Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth (2014, background): “There are conflicting reports about the involvement of MALAT1 in splicing events.(12,24,25) In particular, splicing of the oncogenic transcription factor B-myb was proposed to mediate 0 10 20 30 40 50 60”
- Long non-coding RNA (LncRNA) and cancer: a new paradigm (2017, background): “MALAT1 is also overexpressed in other cancers including bladder carcinoma, breast cancer, prostate cancer, and ovarian cancer, and is a potential biomarker and therapeutic target (85, 91).”
- The rise of regulatory RNA (2014, neutral): “…of lncRNAs in zebrafish and deletion of sequences specifying lncRNAs in mouse have shown that some confer visible developmental defects 181,191,238,239 , although others do not, including knockouts of the widely expressed Neat1 required for paraspeckle function 240 and some of the most highly…”
- Mechanisms of long noncoding RNA function in development and disease (2016, background): “2 Schematic representation of cellular mechanisms involving lncRNAs. a LncRNA transcripts evicting proteins from chromatin; here, pancRNAs prevent DNMT from methylating DNA in their promoter region, thereby ensuring mRNA transcription. b LncRNAs recruiting the Mediator complex to an enhancer region,”