A meta-analysis of cytokines in major depression.

By Y. Dowlati, N. Herrmann, W. Swardfager, Helena Liu, L. Sham, Elyse Reim, K. Lanctôt. Biological Psychiatry, 2010

4,533 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/e550f256d71fd64d3117d401572b827026c3601e

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Citations in the corpus

A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. (2013, neutral): “, 2009), levels of tumour necrosis factor-α (TNF-α) and IL-6 were significantly higher in depressed patients than controls (Dowlati et al., 2010), and blood levels of soluble interleukin-2 receptors, TNF-α and IL-6 were higher in a meta-analysis on patients with major depressive disorder than contro”
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “…data indicate a clear role for inflammation in the etiology and maintenance of fear- and anxietybased disorders, increased inflammation is not specific to these disorders, as other mental health problems, such as depression, are also associated with a pro-inflammatory state (Dowlati et al, 2010).”
Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder (2015, background): “Gender (female/male) Age (cases/controls) Depression diagnosis and severity scale Country Quality score Basterzi AD et al., 2005 1 Outpatients IL-6 46 (23/23) 40/6 33.8 ± 12.8 / 33.6 ± 12.5 DSM-IV, HAM-D Turkey 5 Carvalho LA et al., 2013 2 Inpatients IL-6, IL-10, IL-4, MCP-1 40 (19/21) 28/12 49.05 ±”
Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels (2019, background): “Meta-analyses of crosssectional studies confirm that mean concentrations of circulating CRP and inflammatory cytokines such as interleukin 6 (IL-6) are higher in patients with acute depression compared with controls (Howren et al., 2009; Dowlati et al., 2010; Haapakoski et al., 2015; Goldsmith et al”
Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. (2012, methodology): “We mainly focused on MDD as one previous meta-analysis conducted by Dowlati et al. (2010) included a study with subjects suffering from both depression and substance misuse (Berk et al., 1997).”
Interleukin-6, a Major Cytokine in the Central Nervous System (2012, background): “IL-6 is significantly elevated and highly correlated with major depression [221, 222].”
Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, background): “For IL-1β, no consistent significant association was found in both meta-analyses [59,60].”
Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “…including pro-inflammatory cytokines, acute phase reactant, chemokines and adhesion molecules in the blood and cerebrospinal fluid of both medically ill and medically healthy patients with major depression (Zorrilla et al., 2001; Howren et al., 2009; Miller et al., 2009; Dowlati et al., 2010).”
Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress (2014, neutral): “Proc Natl Acad Sci USA 105(2):751–756.”
A Randomized Controlled Trial of the Tumor Necrosis Factor-alpha Antagonist Infliximab in Treatment Resistant Depression: Role of Baseline Inflammatory Biomarkers (2013, neutral): “(%) Graduate degree 8 (27) 7 (23) College graduate 13 (43) 13 (43) Partial college 8 (27) 9 (30) High school graduate 1 (3) 1 (3) Unemployed (looking for work or disabled), No.”
Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, neutral): “The evidence on immune biomarkers in depression has been synthesized in a number of meta-analyses (Dowlati et al., 2010; Haapakoski et al., 2015; Howren et al., 2009; Köhler et al., 2017).”
Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls (2020, neutral): “2 shows that there was significantly lower CVR in patients using for IL-12; IL-13; sIL-2R; CRP; and IFNγ.”