Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder
By R. Haapakoski, J. Mathieu, H. Alenius, M. Kivimaki. Brain, behavior, and immunity, 2015
995 citations recorded by the source corpus.
Highlights • This meta-analysis confirms a robust link between IL-6, CRP and major depression.• The role of TNF-α and IL-1β in major depression remains uncertain.• Further mechanistic and immunotherapeutic studies on IL-6 and CRP are needed.
Subfields: Behavioral Neuroscience, Biological Psychiatry, Experimental and Cognitive Psychology
View Paper: https://www.semanticscholar.org/paper/08f3f7d4bcdd321bed1554917952cd4242882589
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In Behavioral Neuroscience
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In Biological Psychiatry
In Experimental and Cognitive Psychology
Citations in the corpus
- The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “CRP and TNF have also been associated with greater symptom severity in MDD (Haapakoski et al., 2015).”
- Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls (2020, background): “…of circulating C-reactive protein (CRP), interleukin 6 (IL-6), interleukin-12 (IL-12), tumor necrosis factor-α (TNFα), and reductions in interleukin-4 (IL-4) in acute depression (Howren et al., 2009; Dowlati et al., 2010; Haapakoski et al., 2015; Goldsmith et al., 2016; Köhler et al., 2017).”
- Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels (2019, background): “Meta-analyses of crosssectional studies confirm that mean concentrations of circulating CRP and inflammatory cytokines such as interleukin 6 (IL-6) are higher in patients with acute depression compared with controls (Howren et al., 2009; Dowlati et al., 2010; Haapakoski et al., 2015; Goldsmith et al”