Cell adhesion and motility depend on nanoscale RGD clustering.

By G. Maheshwari, Gillian M Brown, Douglas A. Lauffenburger, A. Wells, L. Griffith. Journal of Cell Science, 2000

885 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e511cfd86ed34c978df8cc26aa5dc769a8e04d74

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Citations in the corpus

• Epithelial contact guidance on well-defined micro- and nanostructured substrates (2003, background): “They offer the advantage of providing well-defined spacings and eliminating the possibility of haphazard ligand clustering relative to smooth substrates coated with integrin binding ligands (Maheshwari et al., 2000; Massia and Hubbell, 1991).”
• Capturing complex 3D tissue physiology in vitro (2006, background): “Some experimental systems have shown that the cell response might be governed not only by the average ligand concentration, but also by local ligand clustering, which might drive integrin clusterin”
• Surface engineering approaches to micropattern surfaces for cell-based assays. (2006, background): “), their surface density [2–4] and spatial distribution [1,5,6] as well as their conformation [7], have been demonstrated to be important surface cues.”
• The role of surface science in bioengineered materials (2002, background): “In another approach star-like PEG tethers modified with different amounts of RGD peptides were attached to glass surfaces, which had been previously covered with a crosslinked PEG hydrogel [53].”
• In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, unknown): “For example, Bradshaw et al. report that functionalization of widely studied RADA16 peptides (RADARADARADARADA) with a fibronectin attachment motif (RADA16-GG-RGDS) or a collagen type-1 derived motif (RADA16-GGFPGERGVEGPGP) leads to significant changes in both proliferation and migration of cultured”
• Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering (2005, background): “Moreover, the fibrillar structure of matrix components brings about adhesion ligand clustering, which has been demonstrated to alter cell behavio”