Origins of chromosome translocations in childhood leukaemia
By M. Greaves, Joe Wiemels. Nature Reviews. Cancer, 2003
727 citations recorded by the source corpus.
Subfields: Hematology, Molecular Biology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/7348d3d2b63f7387619f8a81f11b50e9a791e6d9
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Hematology
In Molecular Biology
- Christopher K. Glass
- Michael G. Rosenfeld
- Ching-Hon Pui
- B. Johansson
- Liuqing Yang
- Jeremy M. Stark
- Jie Zhang
- D. Gilliland
In Public Health, Environmental and Occupational Health
Citations in the corpus
- The impact of translocations and gene fusions on cancer causation (2007, background): “For childhood haematological malignancies, there is ample evidence, based on twin studies and PCR analyses for specific gene fusions in Guthrie spots, that they might be formed in utero several years before overt leukaemi”
- Acute Lymphoblastic Leukemia in Children (2013, background): “Molecular techniques have documented the presence of the same leukemia-specific genetic abnormalities in neonatal blood Guthrie spots and stored cord blood as in diagnostic samples from children with ALL [22].”
- Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer (2009, positive): “Chromosomal translocations, caused by rearrangement of nonhomologous chromosomes (Aplan, 2006), have been well described in leukemia and lymphomas ( Greaves and Wiemels, 2003 ), but their occurrence in solid tumors is increasingly recognized, particularly in prostate cancer (Tomlins et al., 2005).”
- Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair (2008, background): “Finally, since alt-NHEJ appears to play a significant role in therapy-induced oncogenic chromosomal translocations [13], targeting this pathway, again perhaps via CtIP, may enhance the efficacy of such therapy.”
- Leukaemia stem cells and the evolution of cancer-stem-cell research (2005, background): “19 ) and OTT – MAL translocations, as well as constitutional trisomy 21 (Ref”
- Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia (2007, background): “2b): (1) focal deletions involving only PAX5 (25 cases); (2) broader deletions involving PAX5 and a variable number of flanking genes (7 cases); (3) large 9p deletions involving the 39 portion of PAX5 (5 cases); and (4) deletion of all of chromosome 9 or 9p (19 cases).”