Foxp3(+) follicular regulatory T cells control the germinal centre response

By M. Linterman, Wim Pierson, S. K. Lee, A. Kallies, Shimpei Kawamoto, S. Fagarasan, A. Liston, Carola G. Vinuesa, Kenneth G. C. Smith. 2012

628 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e4f4d9f1e92a2bb38bf6ac64eb57df10bfab3d07

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Citations in the corpus

Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses (2014, background): “TIGIT Treg Cells Share Features with Proinflammatory T Cell Lineages Treg cells share a number of features with the effector population they suppress, including the expression of chemokine receptors as well as the transcription factors that induce the development of those effector T cells (Chaudhry ”
GERMINAL CENTER B CELL DYNAMICS (2016, unknown): “A recent development has been the discovery that a subset of GC-resident CD4+ T cells express the regulatory T (Treg) cell master regulator Foxp3, while sharing many phenotypic characteristics of Tfh cells (Chung et al., 2011; Linterman et al., 2011; Wollenberg et al., 2011).”
Gut Microbial Metabolites Fuel Host Antibody Responses. (2016, background): “While Tregs, particularly follicular Tregs, suppress B cell responses (Chung et al., 2011; Lim et al., 2004; Linterman et al., 2011), some Tregs can convert to Tfh cells in PP (Tsuji et al.”
Follicular Helper T Cells. (2016, background): “F or p er so na l u se o nl y. both, include the following: BLIMP1, PD-1, and the helix-loop-helix proteins Id2 and Id3 (209, 214, 215).”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, unknown): “F or p er so na l u se o nl y. Treg Foxp3+ Bcl6+ Foxp3+ GATA3+ IRF4+ Foxp3+ STAT3+ Foxp3+ Tbet+ Foxp3+ Tissuespecific TF+ Environmental response factors: • CXCR5+ • Suppression of antigen-nonspecific germinal center responses • Suppression of Th2 responses under homeostatic conditions • Treg homeost”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “Finally, a subset of CXCR5+ Tregs called follicular regulatory T cells (Tfr) migrates to the germinal center, where they control affinity maturation and differentiation of B cells (232, 233).”