GERMINAL CENTER B CELL DYNAMICS
By L. Mesin, Jonatan Ersching, Gabriel D. Victora. Immunity, 2016
846 citations recorded by the source corpus.
Germinal centers (GCs) are the site of antibody diversification and affinity maturation, and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/b978e9163284f6bf681bb01827a9a71d8d968202
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Citations in the corpus
- Next-Generation Influenza Vaccines. (2020, background): “New insights into lymph node and B-cell biology and better understanding of adjuvants as Toll-like receptor (TLR) agonists are also contributing to more potent and durable vaccine-induced immunity (Mesin et al. 2016; Andrews and McDermott 2018; Del Giudice et al. 2018).”