Reactive oxygen species have a causal role in multiple forms of insulin resistance

By Nicholas Houstis, E. Rosen, Eric S. Lander. Nature, 2006

2,523 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e4ea3008edb9b61de5c28b2a6d1fa23444da006f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. G. Hotamışlıgil
2. B. Spiegelman
3. P. Trayhurn
4. E. Rosen
5. R. Kaufman
6. J. Malhotra
7. Richard J. Johnson
8. Y. Sautin

In Molecular Biology

1. G. Hotamışlıgil
2. R. Kaufman
3. Navdeep S. Chandel
4. J. Malhotra
5. B. Spiegelman
6. Y. Sautin
7. Richard J. Johnson
8. E. Rosen

In Physiology

1. G. Hotamışlıgil
2. B. Spiegelman
3. P. Trayhurn
4. E. Rosen
5. Richard J. Johnson
6. Y. Sautin
7. R. Kaufman
8. Mitchell A. Lazar

Citations in the corpus

• A mitochondrial protein compendium elucidates complex I disease biology (2008, positive): “MitoCarta can also help elucidate the pathogenesis of common degenerative diseases, which have recently been associated with declining mitochondrial gene expression and rising reactive oxygen species production (Houstis et al., 2006; Mootha et al., 2003b; Schon and Manfredi, 2003).”
• Inflammation and metabolic disorders (2006, background): “Oxidative stress is emerging as a feature of obesity and an important factor in the development of insulin resistance in obesit”
• Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease (2014, background): “ROS play a causative role in IR; while antioxidants, including N-acetylcysteine, SOD, and catalase, can improve insulin sensitivity in cultured muscle cells (81).”
• TNF-α and adipocyte biology (2007, background): “Indeed, it has been suggested that production of reactive oxygen species (ROS) contributes to both TNF-α-induced NFκB activation [101] and TNF-α-induced insulin resistance [102] (Fig.”
• From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. (2010, background): “ticoids (219), two agents that induce rapid bone loss.”
• Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword? (2007, positive): “Evidence indicates that oxidative damage is associated with development of insulin resistance and the diabetic state (50, 60, 113).”
• Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, positive): “evidence that reactive oxygen species (ROS) are critical to the effects of TNF-a on insulin signalling((136)), and also that mitochondrial dysfunction is involved((137)).”
• A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. (2007, neutral): “In fact, we observed that LVs from NT-PP mice showed higher levels of MnSOD mRNA and proteins than LVs from CKO-PP mice, indicating a STAT3dependent transcriptional regulation of MnSOD in the postpartum heart.”
• Hypoxia and adipose tissue function and dysfunction in obesity. (2013, background): “Alternative mechanisms for the development of inflammation include endoplasmic reticulum stress (61) and oxidative stress (86).”