Dystrophic microglia in the aging human brain

By Wolfgang Streit, Nicole W Sammons, Amanda J. Kuhns, D. Sparks. Glia, 2004

676 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e4e4ef378ddd78667ae39133bb53f045dcf9283d

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Citations in the corpus

Microglia states and nomenclature: A field at its crossroads (2022, neutral): “167,168 These different morphological types observed in humans were previously described in rodent models (reviewed in Savage et al. 169 ).”
Microglia: biology and pathology (2009, background): “In recent years, the concept of microglia functional plasticity has been expanded with the recognition of a fourth microglial phenotype, termed dystrophic [173] (Figs.”
TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model (2015, neutral): “Microglia contribute to Aβ clearance, at least in the early phases of neurodegeneration (El Khoury et al., 2007); however, the ability of microglia to clear Aβ may wane with age (Streit et al., 2004; Streit and Xue, 2009).”
Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system (2005, background): “The so called microglial dystrophy has been interpreted to suggest microglial senescence and proposed to result in functional defects that trigger an intracerebral inflammatory response that supports the development of age-associated neurodegenerative diseases such as AD (15, 16).”
Para-inflammation in the aging retina. (2009, background): “The incidence of dystrophic microglia increases with age (Streit et al., 2004).”
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease (2009, methodology): “widely expressed by non-activated, ramified (resting) microglia, as well as by dystrophic ones [10, 17, 27, 44],”
Microglia: new roles for the synaptic stripper. (2013, neutral): “These changes in microglial morphology are apparently global and occur throughout the nervous system (Lopes et al., 2008; Streit et al., 2004).”
Microglia derived from aging mice exhibit an altered inflammatory profile (2007, background): “Streit to describe age-induced morphological changes (spheroid formation, gnarling, and fragmentation of processes) in human brains (Streit et al., 2004).”