SUMO--nonclassical ubiquitin.

By F. Melchior. Annual Review of Cell and Developmental Biology, 2000

795 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/e4aaa85e60a94964be2dc045dd761fb7b3985720

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In Epidemiology

1. Aaron Ciechanover
2. M. Glickman
3. C. Sherr
4. A. Dejean
5. J. Seeler
6. H. Ulrich
7. Philipp Stelter

In Molecular Biology

1. J. Massagué
2. George‐Lucian Moldovan
3. J. Seoane
4. D. Wotton
5. B. Pfander
6. S. Jentsch
7. Aaron Ciechanover
8. Shuai Jiang

In Oncology

1. J. Seoane
2. J. Massagué
3. D. Wotton
4. Aaron Ciechanover
5. M. Glickman
6. C. Sherr
7. A. Dejean
8. J. Seeler

Citations in the corpus

• Smad transcription factors. (2005, background): “Two sumoylation consensus motifs ( KxE, where is hydrophobic, x is variable and K is the lysine to be modified [Melchior 2000]) are present in Smad4, one in the MH1 domain, and one in the linker region, and these are the sites of Smad4 sumoylation (Lee et al. 2003; Lin et al. 2003a,b; Ohshima and…”
• Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation (2003, background): “A small ubiquitin-related modifier (SUMO) uses a similar conjugation system that sometimes counteracts the effects of ubiquitinatio”
• GPS-SUMO: a tool for the prediction of sumoylation sites and SUMO-interaction motifs (2014, background): “Theprocess of proteins being covalently modified by SUMOs is called as sumoylation, which is one of the most important and ubiquitous post-translational modifications (PTMs) of proteins (10,11).”
• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “In addition to the ability of PIAS proteins in STAT blocking, they have SUMO E3 ligase activity contributing to a phenomenon named SUMOylation, which is discussed later [83, 84].”
• Nuclear and unclear functions of SUMO (2003, background): “The reader is also referred to prior general review”
• Divorcing ARF and p53: an unsettled case (2006, background): “The covalent addition of SUMO to proteins can generate diverse effects, including alterations in protein transport, interference with ubiquitylation and protein turnover, changes in DNA repair and sister chromatid cohesion, and alterations in gene expression (usually downregulation”
• The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. (2002, background): “This interaction requires the posttranslational conjugation of RanGAP1 with SUMO-1 that serves to target RanGAP1 to the NPC (289, 305).”
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO (2002, background): “This type of modification is widespread and affects a large number of cytosolic and nuclear proteins (for reviews see ref”