The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.

By M. Glickman, Aaron Ciechanover. Physiological Reviews, 2002

4,285 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6a997f8c84d8031bc101ebd40497ad27a31a900c

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Citations in the corpus

TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases (2005, background): “the substrate and mediates ubiquitin transfer to a lysine residue of the target protein.((3)) The large number and variety of”
Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “Ub-protein ligase (E3) enzymes transfer the activated Ub from an Ub-conjugating protein E2, first to a lysine residue of the target protein and then to lysine residues present in the last added ubiquitin, yielding an Ub chain [184].”
Small but versatile: the extraordinary functional and structural diversity of the β-grasp fold (2007, background): “The discovery of covalent modification of eukaryotic proteins by the conjugation of ubiquitin to the (cid:72) -amino groups of target lysines has spawned some of the most exciting directions of research in current molecular biology [1-3].”
Molecular pathophysiology of Parkinson's disease. (2005, background): “E3 ligases are an important part of the cellular machinery that covalently tags target proteins with ubiquitin (Glickman & Ciechanover 2002) (Figure 3).”
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles (2011, methodology): “methods for ubiquitylation site mapping: (1) it only requires a”
A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila (2007, background): “]. Ubiquitin-mediated protein degradation is a tightly regulated process, in which proteins are tagged with ubiquitin moieties through a series of enzymatic reactions involving an E1-activating enzyme, E2-conjugating enzyme, and E3 ubiquitin ligase, which determines substrate specificity. Tagged pro”
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. (2007, background): “The ubiquitin-proteasome pathway degrades both cytosolic and nuclear proteins (Glickman and Ciechanover, 2002), as well as myoﬁbrillar proteins (Solomon and Goldberg, 1996), which comprise most of the protein in adult skeletal muscle.”