The TSC-mTOR signaling pathway regulates the innate inflammatory response.

By T. Weichhart, G. Costantino, M. Poglitsch, M. Rosner, M. Zeyda, K. Stuhlmeier, T. Kolbe, T. Stulnig, W. Hörl, M. Hengstschläger and 2 more. Immunity, 2008

809 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6e2a0522f281a7646375dc6e49a56d1912fe5659

How researchers see this paper

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In Immunology

1. A. Mantovani
2. A. Sica
3. S. Gordon
4. TA Wynn
5. F. Martínez
6. P. Murray
7. Subhra K. Biswas
8. M. Locati

In Molecular Biology

1. M. Laplante
2. David M. Sabatini
3. S. Gordon
4. A. Mantovani
5. A. Sica
6. Subhra K. Biswas
7. G. Raimondi
8. A. Thomson

Citations in the corpus

• Macrophage activation and polarization: nomenclature and experimental guidelines (2014, positive): “However, using the principles described here for systematic investigation of mTOR pathway mutants will most likely resolve why rapamycin-treated macrophages and macrophages from Raptor, Rictor, and TSC1 mutants have diverse phenotypes (Ai et al., 2014; Byles et al., 2013; Festuccia et al., 2014; Wei”
• Immunoregulatory Functions of mTOR Inhibition (2009, background): “Similarly, rapamycin increased IL-12 production and decreased IL-10 production by human DCs stimulated with LPS or Staphylococcus aureus”
• Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript CRP C Reactive Protein CSF Cerebrospinal Fluid DA Dopamine DEX Dexamethasone DST Dexamethasone Suppression Test GR Glucocorticoid Receptor 5-HIAA 5-hydroxyindoleacetic acid HPA Hypothalamic-Pituitary-Adrenal Axis IDO”
• Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization (2017, background): “In an independent study in human macrophages, TSC2 deletion decreased the M1 inflammatory response in an mTOR-dependent manner (61).”
• Regulation of mTORC1 and its impact on gene expression at a glance (2013, background): “J o u rn a l o f C e ll S c ie n c e Similarly, loss of TSC1 or TSC2, which strongly activates mTORC1, was in many studies linked to the elevation of STAT3 phosphorylation (Goncharova et al., 2009; Ma et al., 2010; Onda et al., 2002; Weichhart et al., 2008).”