Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.

By D. Tran, H. Ramsey, E. Shevach. Blood, 2007

856 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/e488b01c858ac13f5d97ba6fc19c4111f2b04343

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In Immunology

1. Shimon Sakaguchi
2. E. Shevach
3. W. E. Paul
4. Jinfang Zhu
5. K. Wing
6. P. Krammer
7. Angelika Schmidt
8. Nina Oberle

Citations in the corpus

• Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “For example, it has been reported that mere TCR stimulation can induce FoxP3 expression in apparently naive human FoxP3 CD4 T cells without conferring suppressive activity (Allan et al., 2007; Gavin et al., 2006; Tran et al., 2007; Wang et al., 2007).”
• Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding (2016, background): “However, some effector T cells transiently express FOXP3 hi upon activation in an inflammatory environment (37, 38).”
• CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation (2013, background): “The transient expression of FoxP3 on CD4 T cells after anti-CD3 stimulation does not always match the induction of suppressive activity (24, 25).”
• Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. (2012, background): “However, Foxp3 expression may not always specify Treg cells; in humans, activated T cells transiently upregulate FOXP3 without acquiring a Treg cell phenotype and function (Allan et al., 2007; Gavin et al., 2006; Tran et al., 2007; Wang et al., 2007; Ziegler, 2006), although such ‘‘promiscuous’’ Fox”
• Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “For example, Shevach’s group found that TCR-induced Foxp3 expression in human naïve Tcons is indeed dependent on TGF-β, but does not result in a suppressive phenotype (Tran et al., 2007).”
• Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells (2010, positive): “Although human CD4Foxp3(2) T cells can be induced to express Foxp3 by stimulation in vitro in the presence of TGF-b, they lack regulatory function (26, 27).”
• Differentiation of Effector CD4 T Cell Populations (2010, positive): “In mice, iTregs show in vitro and in vivo functions similar to those of nTregs (29), but iTregs in humans have thus far failed to demonstrate activity in an in vitro Treg functional assay (30).”