Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity
By M. Schirmer, S. Smeekens, H. Vlamakis, M. Jaeger, M. Oosting, Eric A. Franzosa, R. ter Horst, Trees Jansen, L. Jacobs, M. Bonder and 8 more. Cell, 2016
977 citations recorded by the source corpus.
Summary Gut microbial dysbioses are linked to aberrant immune responses, which are often accompanied by abnormal production of inflammatory cytokines. As part of the Human Functional Genomics Project (HFGP), we investigate how differences in composition and function of gut microbial communities may contribute to inter-individual variation in cytokine responses to microbial stimulations in healthy humans. We observe microbiome-cytokine interaction patterns that are stimulus-specific, cytokine-specific, and cytokine- and stimulus-specific. Validation of two predicted host-microbial interactions reveal that TNFα and IFNγ production are associated with specific microbial metabolic pathways: palmitoleic acid metabolism and tryptophan degradation to tryptophol. Besides providing a resource of predicted microbially-derived mediators that influence immune phenotypes in response to common microorganisms, these data can help to define principles for understanding disease susceptibility. The three HFGP studies presented in this issue lay the groundwork for further studies aimed at understanding the interplay between microbial, genetic, and environmental factors in the regulation of the immune response in humans.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/e3e13305dfb4a983fcfdcc0bfe2e8153cfd4093e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- The Gut Microbiota and Inflammation: An Overview (2020, background): “[107] revealed that people with higher Bifidobacterium adolescentis abundance had a lower TNF-α production.”
- The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “, 2015) and systemic innate and adaptive immune function (Schirmer et al., 2016).”
- The gut microbiota and inflammatory bowel disease (2014, positive): “Currently, there is a lack of knowledge about how exactly these interactions occur and, therefore, about how the gut microbiota is collectively associated with health and disease.(29,30) Based on the findings of Chapter 2, Chapter 3 moves beyond the discovery of independent altered microbial abundan”
- Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19 (2021, positive): “With mounting evidence that gut microorganisms are linked with inflammatory diseases within and beyond the gut, 12 43 these findings underscore an urgent need to understand the specific roles of gut microorganisms in human immune function and systemic inflammation.”
- Mining the human gut microbiota for immunomodulatory organisms (2017, positive): “The gut microbiota plays an important role in educating and modulating the host immune system (Mazmanian et al., 2005; Schirmer et al., 2016).”
- Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy (2017, background): “Human gutmicrobiota are linked to inflammatory cytokine production (Schirmer et al., 2016).”
- Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome (2019, background): “An imbalance of the Th17/Treg correlation and t ir pro-inflamma o y cytokines productio is particularly problematic [57,58], as it either causes initiation or p op gation of disease pathogenesis, suggesting a link between dysbiosis and disease etiology [59–67] (Fig r 2).”