Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse

By J. N. Ferguson, J. Aldag, Thomas R. Insel, L. Young. Journal of Neuroscience, 2001

1,037 citations recorded by the source corpus.

Subfields: Experimental and Cognitive Psychology, Genetics, Social Psychology

View Paper: https://www.semanticscholar.org/paper/e3c29ee57a0d6f1042ddba42b61d8f29db2b855e

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Citations in the corpus

Neuropeptidergic regulation of affiliative behavior and social bonding in animals. (2006, background): “Intriguingly, the knockout mice showed a massive activation of other brain regions, such as the cortex and hippocampus, that was absent in the wild-type mice (Ferguson et al., 2001).”
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans (2005, background): “…et al., 1996) and modulate aggression (Bosch et al., 2005), and mouse knock-outs for oxytocin show a profound social recognition deficit despite normal olfactory and spatial learning abilities that can be fully restored by injection of oxytocin in the medial amygdala (Ferguson et al., 2001).”
Oxytocin increases retention of social cognition in autism. (2007, background): “Interestingly, the findings of Ferguson et al (2001) suggest hat oxytocin specifically plays a role in memory acquisition but ot in memory retrieval.”
A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. (2005, background): “All regions are reciprocally interconnected, have neurons that contain gonadal hormone receptors, and modulate more than one type of affiliative behavior (De Olmos & Heimer 1999; Ferguson et al. 2001; Larsson & Ahlenius 1999; McDonald et al. 1999; Newman 1999; Panksepp 1998; Pfaff 1999; Rolls 1999).”
25 Oxytocin and Vasopressin: Genetics and Behavioral Implications (2006, background): “List of Abbreviations: ACTH, adrenocorticotropic hormone; AH, anterior hypothalamus; AP‐2, activator protein‐2; ATF‐2, activating transcription factor‐2; AVT, arginine vasotocin; BNST, bed nucleus of the stria terminalis; CeM, central amygdala; CNS, central nervous system; CRF, corticotropin releasi”
Oxytocin: the Great Facilitator of Life (2009, positive): “Oxt in the medial amygdala is necessary to facilitate social recognition, as demonstrated by c-fos activation in the medial amygdala of wildtype (WT) but not Oxt KO mice during the initial exposure (Ferguson et al., 2001).”
Consensus Paper: Pathological Role of the Cerebellum in Autism (2012, background): “OTR mouse knockouts show social recognition deficits that can be remediated by oxytocin injections in the medial amygdala [163].”
The neurobiology of pair bonding (2004, neutral): “, and infusions of oxytocin in the medial amygdala completely restore social recognition in these mic”
In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex. (2006, neutral): “The expression of several other immediate early genes such as c-fos and zif-268 have also been used in the literature as an indicator of activated neurons (e.g., Boehm et al., 2005; Choi et al., 2005; Ferguson et al., 2001; Frankland et al., 2004).”
Involvement of estrogen receptor α, β and oxytocin in social discrimination: a detailed behavioral analysis with knockout female mice (2006, background): “As well, behavioral studies have shown that social recognition is impaired in a-ERKO, b-ERKO, and OTKO mice (Choleris et al. 2003; Ferguson et al. 2000, 2001; Imwalle et al. 2002).”