Rhythms of mammalian body temperature can sustain peripheral circadian clocks.
By S. Brown, Gottlieb Zumbrunn, F. Fleury-Olela, Nicolas Preitner, U. Schibler. Current Biology, 2002
605 citations recorded by the source corpus.
BACKGROUND Low-amplitude temperature oscillations can entrain the phase of circadian rhythms in several unicellular and multicellular organisms, including Neurospora and Drosophila. Because mammalian body temperature is subject to circadian variations of 1 degrees C-4 degrees C, we wished to determine whether these temperature cycles could serve as a Zeitgeber for circadian gene expression in peripheral cell types. RESULTS In RAT1 fibroblasts cultured in vitro, circadian gene expression could be established by a square wave temperature rhythm with a (Delta)T of 4 degrees C (12 hr 37 degrees C/12 hr 33 degrees C). To examine whether natural body temperature rhythms can also affect circadian gene expression, we first measured core body temperature cycles in the peritoneal cavities of mice by radiotelemetry. We then reproduced these rhythms with high precision in the liquid medium of cultured fibroblasts for several days by means of a homemade computer-driven incubator. While these "in vivo" temperature rhythms were incapable of establishing circadian gene expression de novo, they could maintain previously induced rhythms for multiple days; by contrast, the rhythms of control cells kept at constant temperature rapidly dampened. Moreover, circadian oscillations of environmental temperature could reentrain circadian clocks in the livers of mice, probably via the changes they imposed upon both body temperature and feeding behavior. Interestingly, these changes in ambient temperature did not affect the phase of the central circadian pacemaker in the suprachiasmatic nucleus (SCN) of the hypothalamus. CONCLUSIONS We postulate that both endogenous and environmental temperature cycles can participate in the synchronization of peripheral clocks in mammals.
Subfields: Aging, Endocrine and Autonomic Systems, Physiology
View Paper: https://www.semanticscholar.org/paper/e3acd5e52b7e4c8357172608b8660411c8d15532
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Citations in the corpus
- Molecular components of the mammalian circadian clock. (2006, background): “As discussed in the Peripheral Clocks section, these rhythms of body temperature fluctuation are sufficient to entrain the peripheral oscillators of homeothermic animals in all cases that have been reported (Brown et al. 2002; Buhr et al. 2010; Granados-Fuentes et al. 2004; Barrett and Takahashi 199”
- Transcriptional regulation of metabolism. (2006, background): “What is the signal that leads to anticipation of food intake with changes in gut motility or in liver gene expression, such as increased expression of Cyp7 hydroxylase and bile acid synthesis? One hypothesis is that the small circadian oscillations in body temperature might be one of these signals (”
- CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “These oscillators can be strongly reset by low-amplitude temperature pulses that mimic the range of circadian variation, and temperature profiles that match circadian body temperature rhythms strongly entrain peripheral clocks (Brown et al. 2002, Buhr et al. 2010).”
- Molecular Architecture of the Mammalian Circadian Clock (2013, background): “A high degree of intercellular coupling among neurons of the SCN forms a neuronal network that is resistant to phase perturbations from internal cues [6], while the phase of peripheral clocks is susceptible to adjustment from the SCN clock via circulating hormones and other metabolic cues [10, 11], ”
- The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “It is thought that circulating factors such as glucocorticoids and the circadian variation in body temperature might function as entraining signals for peripheral clock”
- Suprachiasmatic Nucleus: Cell Autonomy and Network Properties (2010, background): “This is accomplished through diverse pathways, including autonomic neural connections (81) and hormones (82–84), as well as less directly through circadian modulation of body temperature (85) and feeding behavior (86, 87).”
- A web of circadian pacemakers. (2002, neutral): “Circadian clocks Brown et al., 2002).”
- System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock (2007, background): “Of note, body temperature rhythms have previously been shown to contribute to the phase entrainment of peripheral clocks [8], and it is thus tempting to speculate that the molecular mechanism governing temperature-dependent Hsp and/or Cirbp expression are involved in this process.”
- A clockwork web: circadian timing in brain and periphery, in health and disease (2003, background): “, and fibroblast cultures that are incubated in a temperature cycle that reproduces this modification sustain circadian gene expression for longer than those incubated at a constant temperatur”
- The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “Shallow temperature rhythms imitating body temperature fluctuations can maintain previously induced rhythms in peripheral oscillators, and can phase shift peripheral clocks, without affecting the phase of SCN (231).”
- Molecular components of the Mammalian circadian clock. (2013, background): “As discussed in the Peripheral Clocks section, these rhythms of body temperature fluctuation are sufficient to entrain the peripheral oscillators of homeothermic animals in all cases that have been reported (Brown et al. 2002; Buhr et al. 2010; Granados-Fuentes et al. 2004; Barrett and Takahashi 199”