Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-&kgr;B Signaling Through a cAMP-Dependent Pathway

By Noriyuki Ouchi, Shinji Kihara, Y. Arita, Y. Okamoto, K. Maeda, Hiroshi Kuriyama, K. Hotta, M. Nishida, Masahiko Takahashi, M. Muraguchi and 5 more. Circulation, 2000

1,792 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/e38a8b2a82bff0ad882fe4e264fc19fcac8a34cd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. N. Ouchi
2. Jay J Cao
3. J. Bastard
4. F. B. Hu
5. Jerrold M. Olefsky
6. B. Fève
7. N. Rifai
8. H. Fang

In Epidemiology

1. H. Fang
2. R. L. Judd
3. Toshimasa Yamauchi
4. N. Ouchi
5. T. Funahashi
6. I. Shimomura
7. Yuji Matsuzawa
8. S. Kihara

In Immunology

1. Jerrold M. Olefsky
2. G. Hotamisligil
3. H. Fang
4. R. L. Judd

Citations in the corpus

• Adiponectin Regulation and Function (2018, neutral): “Adiponectin decreases TNF-α production in human macrophages (391) and IL-8 in human aortic endothelial cells (HAECs) (137) by inhibiting NF-kB activation (2,233,370,378,391).”
• Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. (2001, background): “Adiponectin is an adipose-specific plasma protein that inhibits the expression of adhesion molecules in endothelial cells and the secretion of TNF-a from monocytemacrophages (16,18,19).”
• Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. (2001, neutral): “A cross-talk between adiponectin and TNF-induced nuclear factor B signaling may be mediated through cAMP-protein kinase A pathway ( 12 ).”
• Effects of obesity on bone metabolism (2011, background): “In contrast adiponectin acts as an anti-inflammatory cytokine which suppresses TNF-a-induced NF-B activation [ 34 ].”
• The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. (2002, background): “Although its exact function is not known, adiponectin/ACRP30 and/or the globular head portion of this protein may promote weight loss in mice (31), stimulate free fatty acid oxidation in muscle, enhance insulin sensitivity (32), and possess anti-inflammatory (33) and antiatherogenic properties (34,3”
• Recent advances in the relationship between obesity, inflammation, and insulin resistance. (2006, background): “Moreover, adiponectin may modulate the TNFa-induced inflammatory response, since it has been shown that adiponectin reduces TNF-a secretion of macrophages [77].”