Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma

By C. Livasy, G. Karaca, R. Nanda, M. Tretiakova, O. Olopade, D. Moore, Charles M. Perou. Modern Pathology, 2006

1,105 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/e3810ebf014c4ed6a55a5c092a4cb8298b8c7b11

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In Cancer Research

In Oncology

In Pathology and Forensic Medicine

Citations in the corpus

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors (2007, background): “Although the human HER2+/ER- tumors are predominantly ER-negative, this comparative genomic analysis and their keratin expression profiles as assessed by immunohistochemistry, suggests that the HER2+/ERhuman tumors are 'luminal' in origin as opposed to showing basal-like features [18].”
Triple-negative breast cancer molecular subtyping and treatment progress (2020, background): “Therefore, it is speculated that EGFR may be a therapeutic target in TNBC [42].”
Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge (2019, background): “TNBC frequently shows morphological features that are characteristic of hypoxia, such as the presence of fibrotic and necrotic areas [108].”
Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas (2007, methodology): “have recently compared 23 basal-like tumors to 33 non-basal-like tumors (defined by gene-expression profiling), and found that basal-like tumors are significantly associated with high mitotic counts; they found geographic necrosis in 74% of the basal-like tumors, pushing margins in 61% and lymphocyt”
Epithelial–mesenchymal plasticity in carcinoma metastasis (2013, background): “Further analysis of these invasive basal/triple-negative subgroups found tumor cells that are double-positive for keratin and vimentin at the invasive front (Sorlie et al. 2001; Livasy et al. 2006; Rakha et al. 2006; Bonnomet et al. 2012).”
Recent advances in therapeutic strategies for triple-negative breast cancer (2022, background): “EGFR Epidermal growth factor receptor (EGFR) is overexpressed in approximately 70–78% of basal-like TNBC samples [74], thus providing a therapeutic target for EGFR-related targeted therapy, although TNBC is characterized by a lack of HER2.”
Triple-negative breast cancer: disease entity or title of convenience? (2010, background): “Typically, they are grade 3, ductal carcinomas with a high mitotic count, high apoptotic rate, geographic or central tumor necrosis (and/or fibrosis), a pushing border of invasion, and a stromal lymphocytic response”
Phylogenetic ctDNA analysis depicts early stage lung cancer evolution (2017, positive): “L Triple negative breast cancers display necrosis 19 , high proliferative indices 20,21 and are associated with increased ctDNA levels compared with other breast cancer subtypes 6 suggesting extension of these observations beyond NSCLC.”
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis (2015, background): “…of mesenchymal marker vimentin and epithelial/luminal markers cytokeratins (CK) 8 and 18, rather than the expression of vimentin alone, correlates with increased invasive and metastatic potential and poor survival and is often observed in many aggressive tumors such as BLBC and melanomas (109–113).”
Descriptive analysis of estrogen receptor (ER)‐negative, progesterone receptor (PR)‐negative, and HER2‐negative invasive breast cancer, the so‐called triple‐negative phenotype (2007, background): “85% of triple-negative phenotypic breast cancers are deemed to be basal-like when tested by appropriate immunohistochemical means.(13,14) To help develop treatment strategies for this subtype of breast cancer, we undertook the present study to better characterize the triple-negative phenotype with r”
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways. (2012, background): “Basal-like tumors tend to be infiltrating ductal carcinomas with a high mitotic index, tumor necrosis, expanding margins and a clear stromal lymphocytic response.(35) The pattern of metastatic relapse is aggressive with predominance for visceral organs, mainly lung, central nervous system and lymph ”