A Toll-like receptor recognizes bacterial DNA

By H. Hemmi, O. Takeuchi, Taro Kawai, T. Kaisho, Shintaro Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda and 1 more. Nature, 2000

6,407 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/e2fc3c2af81d127d73931520f108e5a5ac0cb7a1

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In Immunology

Citations in the corpus

Early-Life Programming of Later-Life Brain and Behavior: A Critical Role for the Immune System (2009, background): “…most importantly, E. coli is capable of activating the immune system independent of (or in addition to) LPS molecules and toll-like-receptor (TLR) 4 signaling (e.g., via TLR 2/5/9; (Hayashi et al., 2001; Hemmi et al., 2000; Steiner et al., 2005), and results in a more prolonged immune response.”
Coronavirus infections and immune responses (2020, background): “More than 10 CDRs distributed in the cytoplasm have been identified, including AIM2‐like receptors (ALRs), DNA‐dependent activator of IFN‐regulatory factor (DAI), interference stimulator of interferon gene (STING), leucine‐rich repeat flightless‐interacting protein 1 (LRRFIP1), DExD/H‐box RNA helica”
Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development (2003, background): “To determine whether any pathogenderived products could affect the ability of bone marrow– derived myeloid or plasmacytoid pDCs to direct Th cell development at medium to low antigen doses, we performed experiments in the presence of the TLR4 ligand LPS (46, 47) and the TLR9 ligand CpG (48).”
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity (2012, background): “Tlr9 –/– mice have been described in another repor”
Pathogen recognition and innate immunity. (2006, neutral): “Bacterial DNA Bacterial genomic DNA is also an immunostimulant and is recognized by TLR9 (Hemmi et al., 2000; Krieg, 2002).”
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway (2002, background): “Among these, TLR4, TLR5 and TLR9 are essential for recognition of lipopolysaccharide (LPS), bacterial flagellin and bacterial DNA containing unmethylated CpG motifs (CpG DNA), respectivel”
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA (2006, background): “Several independent groups have demonstrated that TLR9 is localized in late endosomes or lysosomes, where it detects unmethylated CpG motifs in double-stranded DNA (CpG DNA”
Pattern Recognition Receptors and the Innate Immune Response to Viral Infection (2011, background): “deoxycytidylate-phosphate-deoxyguanylate (CpG) motifs in viral and bacterial DNA [49].”