Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

By J. Markle, D. Frank, Steven Mortin-Toth, C. Robertson, Leah M. Feazel, U. Rolle-Kampczyk, M. von Bergen, K. McCoy, A. Macpherson, J. Danska. Science, 2013

1,896 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e2b78a22dae7c8dd125fb38fe32c453ade669a1b

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In Endocrinology, Diabetes and Metabolism

In Genetics

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Citations in the corpus

Sex differences and hormonal effects on gut microbiota composition in mice (2016, background): “Recent studies with pathogen-free nonobese diabetic (NOD) mice have shown a causal relationship between sex hormones, gut microbiota, and control of autoimmunity.(17,18) Both studies demonstrated that colonization of germ free NOD mice with defined microbiota lead to changes in hormone levels and th”
Role of the Microbiota in Immunity and inflammation (2014, background): “…this sexual dimorphism is also dependent upon the microbiota, as it is not seen in germ-free mice, and the transfer of a male microbiota to females equalizes the incidence of the disease as a result of changes in the expression of sex hormones (Markle et al., 2013; Yurkovetskiy et al., 2013).”
Gender bias in autoimmunity is influenced by microbiota (2013, neutral): “similar to a recently published experiment (Markle et al., 2013), in which ASF does not significantly protect gnotobiotic NODmales from T1D.”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “Human microbial communities are affected by factors such as lifestyle, dietary patterns, antibiotic usage, and by the host genotype, age (Nam et al. 2011), and gender (Mueller et al. 2006; Markle et al. 2013).”
Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases (2019, background): “(547) Intestinal dysbiosis, circulating gut-derived lipopolysaccharides, and weakening of the intestinal mucosal barrier have already been described in patients with AIH(548,549); and changes in the intestinal microbiome have been associated with female bias in autoimmune disease.(550-552) Future in”
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. (2016, positive): “Accordingly, studies inmousemodels have shown that early colonization with a protective microbiota can diminish the risk of autoimmune diabetes development in genetically susceptible animals (Markle et al., 2013).”
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease. (2016, result): “This falls in line with findings from a previous report showing that microbiota from males could partially protect NOD females from diabetes by inducing high levels of circulating testosterone, glycerophospholipids, and sphingolipids [42].”
Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics (2015, positive): “In the average human, bacterial cells outnumber human cells by a 10:1 ratio (Qin et al., 2010), contribute as much as 36% of the active molecules present in the human bloodstream (Hood, 2012), and serve as a source of both pathogen protection (Vaarala, 2012) and risk (Markle et al., 2013).”
Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences (2014, background): “As in other animal models of disease, we found variability in the timing and extent of phenotype emergence with notable gender differences (Markle et al., 2013; Pettersson et al., 2012; Yurkovetskiy et al., 2013).”