Mannose 6-phosphate receptors: new twists in the tale

By P. Ghosh, N. Dahms, S. Kornfeld. Nature reviews. Molecular cell biology, 2003

1,055 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e2a5732a9883f21cb110985a1b2211df32f23fa6

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In Cell Biology

1. T. Braulke
2. P. Boya
3. C. Yap
4. B. Winckler
5. J. Bonifacino
6. Z. Lasiecka
7. Max Vakulenko

In Molecular Biology

1. P. Boya
2. D. Peeper
3. T. Braulke
4. J. Bonifacino
5. T. Kuilman
6. J. Campisi

In Physiology

1. P. Boya
2. D. Peeper
3. J. Bonifacino
4. T. Kuilman
5. J. Campisi
6. Jesús Gil
7. J. Kirkland

Citations in the corpus

• The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. (2012, neutral): “Most nascent lysosomal enzymes bind to mannose-6-phosphate receptors (M6PRs) in the trans-Golgi network (TGN), which traffic the enzymes to early and late endosomes (Ghosh et al., 2003).”
• Senescence-messaging secretome: SMS-ing cellular stress (2009, background): “3a ), and because signalling functions for this growth factor are mainly relayed by IGF1”
• Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor (2004, background): “1, A and C; Ghosh et al., 2003).”
• Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Furthermore, the TGN receives retrograde traffic from the endosomes (both from the lysosomes and the recycling endosomes) (Bonifacino and Rojas, 2006; Ghosh et al., 2003; Mallard et al., 2002) and is therefore at a crucial crossroad for membrane transport in and out of cells.”
• Lysosomes: fusion and function (2007, background): “Many of the proteins in the mammalian trafficking machinery are orthologues of those used by Saccharomyces cerevisiae for delivery from the Golgi to the vacuole (the yeast equivalent of the mammalian lysosome”
• Sorting of lysosomal proteins. (2009, background): “transport intermediates for endosomal delivery is dependent on sorting signals present in the cytosolic tails of bothMPR [27].”
• Lysosomal membrane permeabilization and cell death (2018, background): “Lysosomal hydrolases free from MRPs are further delivered to lysosomes, which can be therefore distinguished from endosomes by their lack of MPRs.(12) The delivery of lysosomal membrane proteins remains poorly understood, and is thought to be mediated indirectly via the plasma membrane or directly v”