CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.

By L. Shiow, D. Rosen, Naděžda Brdičková, Ying Xu, Jinping An, L. Lanier, J. Cyster, M. Matloubian. Nature, 2006

642 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e276bce73a07f9dcd2fe7eaae4c9e872a6a634a5

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Citations in the corpus

Immunology of COVID-19: Current State of the Science (2020, unknown): “Cytokines such as IFN-I and TNF-a may inhibit T cell recirculation in blood by promoting retention in lymphoid organs and attachment to endothelium (Kamphuis et al., 2006; Shiow et al., 2006).”
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse (2011, background): “Given this, it is unclear why iNKT cells express intermediate levels of the T cell activation marker CD69, although it is well established that other stimuli can induce CD69 (Shiow et al., 2006).”
Human T cell development, localization, and function throughout life (2018, background): “, 2014), which can promote retention through sequestration of the sphingosine-1-S1PR1 (Mackay et al., 2015; Shiow et al., 2006).”
The mTOR kinase determines effector versus memory cell fate of CD8+ T cells by regulating T-bet and Eomesodermin expression (2010, methodology): “…using markers associated with memory precursor CD8+ T cells, i.e., CD62L (lymph node homing) (Wherry et al., 2003), CD69 (lymph node retention) (Shiow et al., 2006), CD127 (IL-7Ra; essential for memory T cell maintenance) (Schluns et al., 2000), CD122 (IL-15Rb and essential for memory CD8+ T…”
Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites (2017, background): “CD69 has also been shown to have tissue-retention functions in lymph nodes through sequestration of the sphingosine1-P receptor (S1PR) that mediates egress of T cells (Matloubian et al., 2004; Shiow et al., 2006) and is required for TRM retention in the skin (Mackay et al.”