Immunology of COVID-19: Current State of the Science
By Nicolas Vabret, G. Britton, C. Gruber, Samarth Hegde, Joel Kim, M. Kuksin, Rachel M. Levantovsky, L. Malle, A. Moreira, Matthew D. Park and 21 more. Immunity, 2020
1,500 citations recorded by the source corpus.
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.
Subfields: Infectious Diseases, Obstetrics and Gynecology
View Paper: https://www.semanticscholar.org/paper/b82c11be00408faed6613e2a74029601079e4676
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In Infectious Diseases
Citations in the corpus
- IL-6 in inflammation, autoimmunity and cancer (2020, background): “Consistent with the notion that severe COVID-19 is a cytokine storm syndrome (12–17, 336 ), SARS-CoV-1 and MERS-CoV activate NF-κ B in a manner dependent on MyD88 through PRRs, such as retinoic acid-inducible gene I protein (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), leading…”
- Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships (2020, background): “tein allows viral replication not only in the respiratory tract but also in other tissues expressing ACE2, including the intestinal enterocytes, liver, heart and kidneys.(109,142) This mechanism is thought to drive”