Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism.

By P. Ježek, L. Hlavatá. International Journal of Biochemistry and Cell Biology, 2005

763 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e23995702c9923e80cf5103f9a45d6c1489a0633

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Citations in the corpus

Reactive oxygen species in plants: their generation, signal transduction, and scavenging mechanisms (2011, background): “…(1) O2 consumption via cytochrome oxidase to produce H2O, a process that accounts for more than 95% of O2 consumption under normal conditions; and (2) direct reduction of O2 to O2˙ˉ in the flavoprotein region of the NADH dehydrogenase segment of the respiratory chain (Jezek and Hlavata, 2005).”
Cadmium stress: an oxidative challenge (2010, neutral): “Mitochondrial ROS production Mitochondria are a major cellular site of ROS production, but the quantity produced under normal and stress conditions is unknown (Fleury et al. 2002; Kehrer 2000; Ježek and Hlavatá 2005; Gao et al. 2008).”
Mitochondrial dysfunction and oxidative stress in metabolic disorders - A Step towards mitochondria based therapeutic strategies (2016, background): “Also, recent studies have indicated abnormal mitochondrial dynamics along with overproduction of ROS in diabetic patients [93,120].”
The sites and topology of mitochondrial superoxide production (2010, background): “Seven specific sites that are involved in ROS generation have been defined in isolated mammalian mitochondria using electron transport chain inhibitors (Andreyev et al., 2005; Brand et al., 2004; Jezek and Hlavata, 2005; Murphy, 2009; Raha and Robinson, 2000; Turrens, 2003), but we lack reliable mea”
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, background): “As a consequence, they are also the primary source of cellular reactive oxygen species (ROS), especially at level of the respiratory chain complexes I and III, where electrons derived from NADH and ubiquinone can directly react with oxygen or other electron acceptors and generate free radicals [3, 4”
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. (2006, background): “Mitochondria are the major source of ROS within the cell [69,70].”
Peroxisomes and oxidative stress. (2006, background): “In particular H2O2, which is not harmful until converted to more reactive ROS, acts on cellular thioldisulfide redox buffer systems such as glutathione, thioredoxin and peroxiredoxin (for review see [5,6]).”
Endothelial dysfunction - a major mediator of diabetic vascular disease. (2013, background): “The most important sources of ROS generation in the vasculature include the mitochondrial electron transport chain [115-117], NADPH oxidases [118-120] and xanthine oxidase [109,121].”