Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

By W. Shen, M. Flajolet, Paul Greengard, D. Surmeier. 2008

1,202 citations recorded by the source corpus.

At synapses between cortical pyramidal neurons and principal striatal medium spiny neurons (MSNs), postsynaptic D1 and D2 dopamine (DA) receptors are postulated to be necessary for the induction of long-term potentiation and depression, respectively—forms of plasticity thought to underlie associative learning. Because these receptors are restricted to two distinct MSN populations, this postulate demands that synaptic plasticity be unidirectional in each cell type. Using brain slices from DA receptor transgenic mice, we show that this is not the case. Rather, DA plays complementary roles in these two types of MSN to ensure that synaptic plasticity is bidirectional and Hebbian. In models of Parkinson's disease, this system is thrown out of balance, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms.

Subfields: Cellular and Molecular Neuroscience, Neurology

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Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “Taken together, these findings indicate that neuromodulation in the mushroom body instructs opposing forms of synaptic plasticity, analogous to the bidirectional tuning of synaptic strength by dopamine in mammalian brain centers (Huang et al., 2004; Shen et al., 2008; Tritsch and Sabatini, 2012).”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “In the vertebrate basal ganglia, dopamine dependent synaptic plasticity important for aversive and appetitive learning is known to result in both synaptic potentiation and synaptic depression (Shen et al., 2008).”
The Neuroscience of Drug Reward and Addiction. (2019, neutral): “…NAc binds to both D1R-expressing MSNs, where DA is stimulatory (increases cAMP and intracellular Ca signaling), and D2R-expressing MSNs where DA is inhibitory (decreases cAMP and intracellular Ca signaling) (213, 245, 297, 298), sparking the motivation to initiate reward-directed behaviors (346).”
GABA Neurons of the VTA Drive Conditioned Place Aversion (2012, background): “As in the striatum, there may be some form of synaptic plasticity in the amygdala that can only be expressed in the absence of DA signaling (Shen et al., 2008).”
Stable Learning in Stochastic Network States (2012, background): “…is biological evidence in both vertebrates and invertebrates that STDP is modulated by neuromodulators (Seol et al., 2007; Pawlak and Kerr, 2008; Shen et al., 2008; Zhang et al., 2009; Pawlak et al., 2010; S. Cassenaer, and G. Laurent, personal communication), which are known to be key factors…”
Conditional modulation of spike-timing-dependent plasticity for olfactory learning (2012, background): “The functional form of STDP has recently been shown to depend on neuromodulatory context in mammalian brain slice”
Dopamine, Affordance and Active Inference (2012, background): “Key examples here include the opposing effects of the direct and indirect pathways [128,129] and the opposing influences of dopamine on synaptic plasticity [56].”
Neural basis of reinforcement learning and decision making. (2012, background): “…1993, Schultz 2006, Haber et al. 2000, Haber & Knutson 2010), and multiple types of dopamine receptors in the striatum can modulate the plasticity of corticostriatal synapses accordingo the relative timing of presynaptic vs. postsynaptic action potentials (Shen et al. 2008, Gerfen & Surmeier 2011).”
Dopamine in motivational control: rewarding, aversive, and alerting (2010, background): “In an analogous manner, low DA receptor activation promotes potentiation of corticostriatal synapses onto the indirect pathway (Shen et al., 2008) and learning from negative outcomes (Frank et al., 2004; Voon et al., 2010), while striatal D2 receptor blockade selectively suppresses movements to…”
A computational model of inhibitory control in frontal cortex and basal ganglia. (2011, neutral): “…& Hikosaka, 2006; Palminteri et al., 2009; Voon et al., 2010), and synaptic plasticity and opto-genetic and genetic engineering studies in rodents (Hikida, Kimura, Wada, Funabiki, & Nakanishi, 2010; Kravitz et al., 2010; Kravitz, Tye, & Kreitzer, 2012; Shen, Flajolet, Greengard, & Surmeier, 2008).”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (positive): “However, several studies describe an effect of neuromodulators on STDP while inhibition is blocked, indicating at least one alternative mode of action of neuromodulators (Pawlak and Kerr, 2008; Shen et al., 2008).”
Neuronal Reward and Decision Signals: From Theories to Data. (2015, background): “Reinforcement models distinguishing between direct and indirect striatal pathways are based on in vitro work (424, 540) and assume that dopamine prediction error signals have differential plasticity effects on D1 versus D2 receptor expressing striatal neurons (72) and induce the learning of respecti”