GABA Neurons of the VTA Drive Conditioned Place Aversion
By Kelly R. Tan, Cédric Yvon, Marc Turiault, J. J. Mirzabekov, J. Doehner, G. Labouèbe, Karl Deisseroth, K. Tye, C. Lüscher. Neuron, 2012
625 citations recorded by the source corpus.
SUMMARY Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABAA receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/812a23eddc692d6d43115b8a5e83253851088201
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In Cellular and Molecular Neuroscience
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In Molecular Biology
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Citations in the corpus
- Neuronal Reward and Decision Signals: From Theories to Data. (2015, methodology): “Some of these inputs are activated by aversive stimuli (10, 102, 582).”
- Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input–Output Mapping (2015, background): “VTA-DA and VTA-GABA neurons have distinct firing patterns in vivo (Cohen et al., 2012), and their optogenetic activation produces opposing behavioral effects (Tsai et al., 2009; Tan et al., 2012).”
- The mysterious motivational functions of mesolimbic dopamine. (2012, neutral): “However, it is not clear if this effect is specifically due to dopaminergic actions, or if it is dependent upon aversive effects that also are produced with this manipulation (Tan et al., 2012).”
- Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors (2018, methodology): “To induce transient inhibition of VTA DAergic neurons, we optogenetically stimulated VTA GABAergic neurons in VGAT::IRES-Cre mice (29) (Fig.”