A computational model of inhibitory control in frontal cortex and basal ganglia.
By Thomas V. Wiecki, Michael J Frank. Psychology Review, 2011
371 citations recorded by the source corpus.
Planning and executing volitional actions in the face of conflicting habitual responses is a critical aspect of human behavior. At the core of the interplay between these 2 control systems lies an override mechanism that can suppress the habitual action selection process and allow executive control to take over. Here, we construct a neural circuit model informed by behavioral and electrophysiological data collected on various response inhibition paradigms. This model extends a well-established model of action selection in the basal ganglia by including a frontal executive control network that integrates information about sensory input and task rules to facilitate well-informed decision making via the oculomotor system. Our simulations of the anti-saccade, Simon, and saccade-override tasks ensue in conflict between a prepotent and controlled response that causes the network to pause action selection via projections to the subthalamic nucleus. Our model reproduces key behavioral and electrophysiological patterns and their sensitivity to lesions and pharmacological manipulations. Finally, we show how this network can be extended to include the inferior frontal cortex to simulate key qualitative patterns of global response inhibition demands as required in the stop-signal task.
Subfields: Cognitive Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/c65ecfc919d5158c7d215375c7b922648d3aecef
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Citations in the corpus
- Executive functions and the generation of “random” sequential responses: A computational account (2016, neutral): “…Gilbert & Shallice, 2002; Brown, Reynolds & Braver, 2007; Altmann & Gray, 2008; Herd et al., 2014; memory maintenance and updating: Ashby, Ell, Valentin & Casale, 2005; O’Reilly & Frank, 2006; response inhibition: Band et al., 2003; Boucher, Palmeri, Logan & Schall, 2007; Wiecki & Frank, 2013).”
- Computational models of basal-ganglia pathway functions: focus on functional neuroanatomy (2013, background): “Along similar lines, the hyperdirect pathway has been hypothesized to globally inhibit prepared responses when a stop signal is shown before response execution (Aron and Poldrack, 2006; Aron, 2011; Wiecki and Frank, 2013).”
- The expected value of control: An integrative theory of anterior cingulate cortex function (2013, neutral): “Several studies have shown that dACC interacts directly with structures proposed to implement changes of threshold, such as the subthalamic nucleus (Aron et al., 2007; Aron and Poldrack, 2006; Cavanagh et al., 2011; Jahfari et al., 2011; Wiecki and Frank, 2013), as well as those thought to influence”