Mammalian cyclin-dependent kinases.

By Marcos Malumbres, M. Barbacid. TIBS -Trends in Biochemical Sciences. Regular ed, 2005

1,286 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/e1639410e70f90bc291704793ad7626cd2db181a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Marcos Malumbres
2. M. Barbacid
3. Wolf-Dietrich Heyer

In Molecular Biology

1. Marcos Malumbres
2. M. Barbacid
3. Vincenzo Belcastro
4. J. León
5. Wolf-Dietrich Heyer
6. Minoru Yoshida
7. Jie Liu
8. M. Matzuk

In Oncology

1. Marcos Malumbres
2. M. Barbacid
3. Wolf-Dietrich Heyer

Citations in the corpus

• Emerging roles of E2Fs in cancer: an exit from cell cycle control (2009, neutral): “Thereafter, numerous studies focusing on how E2Fs contribute to cell proliferation elucidated a molecular signalling network that converged on the post-translational modifications of RB and RB-related proteins (which are mediated by cyclin–CDK complexes) and the subsequent waves of E2F-dependent tra”
• Genome-wide association analysis identifies 20 loci that influence adult height (2008, neutral): “The genes implicate a number of biological pathways and processes in the normal determination of human height, including Hedgehog signaling ( IHH, HHIP, PTCH1) , basic cell cycle regulation ( CDK6 , one of the cyclin-dependent kinases implicated in cell cycle progressio”
• CDC25 phosphatases in cancer cells: key players? Good targets? (2007, background): “CDK complexes are key regulators of cell-cycle progression, and are held inactive by the phosphorylation of two residues located within the ATP binding loop (Thr14 and Tyr15 of CDK1 ), by the WEE1 and MYT1 kinase”
• Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA (2007, background): “For instance, CDK2 is activated upon associating with cyclin E or A, whereas CDK4 and CDK6 are activated by D-type cyclin”
• Regulation of homologous recombination in eukaryotes (2010, background): “IR: ionizing radiation CDK drives directional progress through the cell cycle, dependent on the expression of stage-specific cyclins that modulate CDK activity and impart substrate specificity (101, 163).”
• Cyclin D-CDK4 kinase destabilizes PD-L1 via Cul3SPOP to control cancer immune surveillance (2017, neutral): “Cyclin-dependent kinases play crucial roles in regulating the stability of cell cycle-related proteins during cell cycle progression 14,15 .”
• The mammalian ovary from genesis to revelation. (2009, background): “CDK1 is negatively regulated through phosphorylation on Thr14 and Tyr15.”
• Discovery of drug mode of action and drug repositioning from transcriptional responses (2010, background): “CDKs are key regulators of cell cycle progression: CDK2 and CDK4 are responsible for phosphorylation of the Retinoblas-toma (RB) protein, causing activation of the E2F transcription factor and transcription of genes involved in G1/S transition and initiation of DNA replication (32).”
• Cyclin-dependent kinases (2014, background): “Like its yeast ortholog, Cdk1 is the only CDK essential for the cell cycle in mammals [9], whereas both Cdk2 and Cdk3 are dispensable [3,10].”
• Myc and cell cycle control. (2015, background): “To date, there are 21 genes encoding Cdks and 29 genes encoding cyclins in the human genome [1,2].”
• Cell cycle, CDKs and cancer: a changing paradigm (2009, background): “These three basic cell cycle defects — unscheduled proliferation, GIN and CIN — are mediated, directly or indirectly, by misregulation of cyclin-dependent kinases (CDKs”