Genome-wide association analysis identifies 20 loci that influence adult height

By M. Weedon, H. Lango, Cecilia M. Lindgren, Chris Wallace, David M. Evans, M. Mangino, R. Freathy, J. Perry, Suzanne E Stevens, A. Hall and 19 more. Nature Genetics, 2008

819 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/644e52acb1b7af618648dff5a1c8aefd4cc1643e

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Citations in the corpus

Mapping complex disease traits with global gene expression (2009, background): “The combined effects of the 20 SNPs explained only 3% of height variation, taking into account such factors as age and populatio”
Hedgehog Signaling in Development and Cancer (2008, neutral): “Mutations in Hh pathway components, including Ptc1 and Smo, leading to pathway activation have been linked to basal cell carcinoma and medulloblastoma (Wicking et al., 1999).”
Intelligence: new findings and theoretical developments. (2012, background): “This was the case despite the fact that height is over 90% heritable in the population studied (Weedon et al., 2008).”
Analysing biological pathways in genome-wide association studies (2010, background): “Interestingly, the Hedgehog signalling, extracellular matrix and cancer pathways each contain several candidate genes, suggesting that these pathways may be involved in human growth and developmental processe”
Using multiple genetic variants as instrumental variables for modifiable risk factors (2012, methodology): “With increasing availability of multiple genetic variants associated with the same risk factor or disease outcome, it is becoming common for genetic association studies to report associations with allele scores.(64,65) Before an allele score is used as an IV the joint validity of the SNPs should be ”
Rare and Common Variants: Twenty arguments (2011, background): “php/Main_Page">GIANT Consortium confirmed the inferences from 30,000 individual”
Genomic Selection Accuracy using Multifamily Prediction Models in a Wheat Breeding Program (2011, background): “Despite a high h2 (~0.80) and a TP of tens of thousands of individuals, only ~5% of the phenotypic variance for human height has been accounted for with ~50 signifi - cant markers (Gudbjartsson et al., 2008; Lettre et al., 2008; Weedon et al., 2008; Visscher, 2008).”