Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

By D. Kaida, H. Motoyoshi, E. Tashiro, Takayuki Nojima, M. Hagiwara, K. Ishigami, Hidenori Watanabe, T. Kitahara, Tatsuhiko Yoshida, H. Nakajima and 3 more. Nature Chemical Biology, 2007

632 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/72965092628edc686c51e9e292a6fc04543a93f8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Xose S. Puente
2. C. López‐Otín
3. Minoru Yoshida
4. Alfonso Valencia
5. Heinz Himmelbauer
6. M. Doi
7. Ivo G. Gut
8. Joël Janin

Citations in the corpus

• Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia (2011, background): “Lys700Glu, are also detected in solid tumors and that SF3B1 is the target of antitumor drug”
• RNA-methylation-dependent RNA processing controls the speed of the circadian clock. (2013, positive): “Tentatively, we tested the splicing inhibitor spliceostatin A (Kaida et al., 2007) on PER2::LUC MEFs.”