A deoxyribozyme-based molecular automaton

By Milan N. Stojanovic, Darko Stefanovic. Nature Biotechnology, 2003

572 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e153ceaa9a50f57153ae042b83a40d2af2445a1a

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In Molecular Biology

Citations in the corpus

DNA computing circuits using libraries of DNAzyme subunits. (2010, methodology): “This was demonstrated by applying the same two inputs (I3 and I4) in a system with a library of DNAzyme subunits (1)–(4) and (8)–(10) and a collection of substrates (12), (5) and (11), each labelled with a different fluorophore (F1, F2, F3).”
An autonomous molecular computer for logical control of gene expression (2004, methodology): “We also note an alternative approach to sensing biochemical signals, known as ‘chemical logic gates&rsquo”
Programmable chemical controllers made from DNA (2013, background): “These mechanisms of faithful transmission stabilize cultural knowledge, thus enabling successive improvements, as has been previously shown theoretically 18 and empirically 19,20 .”
A BIRD’S EYE VIEW: TRACKING SLOW NANOMETER-SCALE MOVEMENTS OF SINGLE MOLECULAR NANO-ASSEMBLIES (2010, unknown): “deoxyribozymes may be utilized for programming purposes (Stojanovic and Stefanovic, 2003).”
Thermodynamic Analysis of Interacting Nucleic Acid Strands (2007, background): “Remarkably, empirical potential functions based on secondary structure alone [41, 31, 23] have great utility for studying the properties of natural and engineered RNA and DNA structures [23, 40, 36, 35, 12].”
Neural network computation with DNA strand displacement cascades (2011, unknown): “5, {1, 1, 1, 1}] reporterREST[36, 21, 6, 5] reporterREST[39, 22, 23, 1] reporterREST[43, 30, 24, 13] reporterREST[44, 31, 25, 8] conc[w53,5] = 5 × x(1)1 × c conc[w34,18] = 5 × x1 × c conc[w10,1] = 5 × x(1)2 × c conc[w40,27] = 5 × x2 × c conc[w26,13] = 5 × x(1)3 × c conc[w41,28] = 5 × x3 × c conc[w20”
Molecular logic and computing. (2007, background): “The logic basis of numeracy has been expanded into gamin”
Dynamic DNA nanotechnology using strand-displacement reactions. (2011, methodology): “and used these gates in combination to form a variety of logic circuit”
A universal RNAi-based logic evaluator that operates in mammalian cells (2007, background): “dtd" [ ]> A molecular automaton is an engineered molecular system coupled to a (bio)molecular environment by “flow of incoming messages and the actions of outgoing messages,” where the incoming messages are processed by an “intermediate set of elements,” that is, ”