Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells

By L. Hilenski, R. Clempus, M. Quinn, J. Lambeth, K. Griendling. Arteriosclerosis, Thrombosis and Vascular Biology, 2004

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Crosstalk between mitochondria and NADPH oxidases (2011, background): “Nox4 is colocalized with the p22phox subunit, which is required for Nox4 activity [93,101].”
Nox proteins in signal transduction (2009, positive): “Nox4 has been identified in focal adhesions [27], the nucleus [32], and the endoplasmic reticulum [33], where it interacts with kinases and phosphatases distinct from those found in caveolae and endosomes.”
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, positive): “Nox4 for instance, whose activity is independent of p47 phox , concentrates within focal adhesions in smooth muscle cells (Hilenski et al., 2004).”
Chemistry and biology of reactive oxygen species in signaling or stress responses (2011, background): “This also prevents oxidation of pathological targets such as nucleotides that are confined to other parts of the cel”
Reactive oxygen species in vascular biology: implications in hypertension (2004, positive): “Recent studies demonstrated that the newly discovered gp91phox (Nox2) homologs, Nox1, Nox4, and Nox5 (Nox for NAD(P)H Oxidase) are found in the vasculature (Suh et al. 1999; Cheng et al. 2001; Ago et al. 2004; Hilenski et al. 2004).”
Redox signaling in hypertension. (2006, background): “Oscillatory shear stress increases expression of p22phox, gp91phox and Nox4 in endothelial cells, whilst pulsatile shear stress downregulates these subunits [59,60].”