Elevated C-Reactive Protein Levels and Impaired Endothelial Vasoreactivity in Patients With Coronary Artery Disease

By S. Fichtlscherer, Gunter Rosenberger, D. Walter, S. Breuer, Stefanie Dimmeler, A. Zeiher. Circulation, 2000

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Endothelial Dysfunction: Cardiovascular Risk Factors, Therapy, and Outcome (2005, neutral): “More recently, endothelial dysfunction has also been associated with obesity, elevated C-reactive protein, and chronic systemic infection (Celermajer et al 1992; Steinberg et al 1996; Thogersen et al 1998; Cushman et al 1999; Fichtlscherer et al 2000; Al Suwaidi et al 2001; Prasad et al 2002).”
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. (2001, background): “Elevated CRP levels have been similarly associated with blunted endothelial vasoreactivity and, perhaps more importantly, CRP normalization is associated with subsequent improvement of regional blood flow.(47) In addition, crosssectional analyses show that CRP is Figure 2.”
The clinical implications of endothelial dysfunction. (2003, background): “mation, including increased levels of C-reactive protein (7), are also associated with endothelial dysfunction in human subjects (8,42,43).”