The clinical implications of endothelial dysfunction.
By Michael E. Widlansky, N. Gokce, J. Keaney, J. Vita. Journal of the American College of Cardiology, 2003
1,803 citations recorded by the source corpus.
Defining new approaches for the prevention and treatment of atherosclerosis is an important priority. Recently, measurement of endothelial function in patients has emerged as a useful tool for atherosclerosis research. Risk factors are associated with impaired endothelial function, and clinical syndromes relate, in part, to a loss of endothelial control of vascular homeostasis. Recent studies have shown that the severity of endothelial dysfunction relates to cardiovascular risk. A growing number of interventions known to reduce cardiovascular risk have been shown to improve endothelial function. This work suggests that studies of endothelial function could be used in the care of patients and as a surrogate marker for the evaluation of new therapeutic strategies. This article will review this growing literature in an effort to evaluate the current clinical utility of endothelial dysfunction.
Subfields: Cardiology and Cardiovascular Medicine, Epidemiology
View Paper: https://www.semanticscholar.org/paper/7672c5293cf6491163d22857516ec7346a342b90
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In Cardiology and Cardiovascular Medicine
In Epidemiology
Citations in the corpus
- The Vascular Endothelium and Human Diseases (2013, background): “Importantly, such abnormalities can be reversed over weeks to months with risk-reduction therapy; even if lesion regression does not occur (24).”
- Effect of exercise training on endothelium‐derived nitric oxide function in humans (2004, background): “…1996; Watts et al. 1996; Williams et al. 1996; O’Driscoll et al. 1999) and obesity (Arcaro et al. 1999; Perticone et al. 2001a) are associated with impaired NO-vasodilator function and treatment with pharmacological agents can reverse this (O’Driscoll et al. 1997a,b, 1999; Widlansky et al. 2003).”
- Obesity, metabolic syndrome, and cardiovascular disease. (2004, background): “It is believed by many workers that endothelial dysfunction is somehow involved in the atherogenic process (41).”
- Health effects of particulate air pollution: A review of epidemiological evidence (2011, background): “…is associated with a number of vascular changes, such as decreased vasodilatation, development of prothrombotic and proinflammatory states, and smooth muscle cell proliferation, all of which contribute to the formation and progression of chronic atherosclerotic lesions (Widlansky et al., 2003).”
- The Endothelium and Its Role in Regulating Vascular Tone (2010, background): “In addition, assessments of endothelial function are good predictors of future cardiac events in individuals at risk of CVD and those with established CVD [99, 100], and ED is common in individuals with CVD risk factors [101].”
- Predictive Value of Brachial Flow-Mediated Dilation for Incident Cardiovascular Events in a Population-Based Study: The Multi-Ethnic Study of Atherosclerosis (2009, background): “010); (3) age, sex, diabetes mellitus, smoking status, LDL cholesterol, HDL cholesterol, triglycerides, systolic blood pressure, use of hypertension medications, resting heart rate, and statin use (the full model); and (4) the FRS (hazard ratio, 0.”
- The relationship between shear stress and flow‐mediated dilatation: implications for the assessment of endothelial function (2005, background): “exercise) have been demonstrated at the group level (Widlansky et al. 2003; Green et al. 2004); however, day to day variability in subject responses may limit the utility of using reactive hyperaemia testing to track an individual’s improvement in response to an intervention (Hijmering et al.”