C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.

By A. Pradhan, JoAnn E. Manson, N. Rifai, J. Buring, P. Ridker. Journal of the American Medical Association (JAMA), 2001

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Interleukin-6 induces cellular insulin resistance in hepatocytes. (2002, background): “Of these proinflammatory cytokines, IL-6 has been shown to have the strongest correlation with insulin resistance and type 2 diabetes (5,9,10).”
Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, positive): “IL-6 is another classical pro-inflammatory cytokine that is a risk factor for the development of T2D in human [25].”
Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels (2019, background): “In addition to depression and CVD, inflammation is associated with other physical and psychiatric disorders including diabetes mellitus (Pradhan et al., 2001), schizophrenia (Miller et al.”
Role of C-Reactive Protein at Sites of Inflammation and Infection (2018, background): “CRP also has the ability to recognize self and foreign molecules based on the pattern recognition, something that other activators of complement such as IgG cannot achieve because these molecules only recognize distinct antigenic epitopes (56).”